An age-period-cohort analysis of trends in psychedelic and ecstasy use in the Australian population.
G. Chan, Tianze Sun, Carmen C. W. Lim, W. Yuen, Daniel Stjepanović, Brienna N. Rutherford, Wayne Hall, Ben Johnson, J. Leung
Addictive Behaviors December 1, 2021 DOI: 10.1016/j.addbeh.2021.107216 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Repeated cross-sectional nationally representative household survey with age-period-cohort analysis Peer reviewed |
|---|---|
| Sample size | 149,296 |
| Population | Australian household survey respondents aged 18 to 80 years |
| Topics | MDMA |
| Key findings | Past-year use of both psychedelics and ecstasy decreased with age. Ecstasy use showed significant period variation with no clear trend and a birth cohort pattern that peaked in the 1971-80 cohort before declining in the 1991-2001 cohort. Psychedelic use showed a significant upward trend across survey periods and similarly high prevalence in the three most recent birth cohorts. |
Abstract
Aim: To test the age, cohort, and period effect on past-year use trends in psychedelic drugs and ecstasy.
Method: Data were from a repeated cross-sectional nationally representative household survey in Australia conducted every three years between 2001 and 2019. An age-period-cohort model was used to test the effect of age, birth cohort, and period on past year psychedelic and ecstasy use. Participants were between 18 and 80 years old at the time of the survey. The total sample size was 149,296 (Mean age = 45.8; 56% female). Past-year use of psychedelics and ecstasy were the key outcome variables. There were six birth cohorts that were derived in each survey: 1936-50, 1951-60, 1961-70, 1971-80, 1981-90, and 1991-2001. There were seven periods that coincided with survey years: 2001, 2004, 2007, 2010, 2013, 2016 and 2019. Age was treated as continuous.
Results: Past-year use of both psychedelics and ecstasy decreased with age, b = -0.87, 95% CI [-1.14, -0.61] and b = -0.84, 95% CI [-1.08, -0.60]. For ecstasy, while there was significant variation across periods (p < .001), there was no obvious trend. There was a significant birth cohort effect (p < .001), with prevalence increasing from the 1936-50 cohort, peaking in the 1971-80 cohort and then decreasing in the 1991-2001 cohort. For psychedelics, there was significant variation across periods (p < .001) with an upward trend. There was a significant birth cohort effect (p < .001), with prevalence increasing from the 1936-50 cohort to similarly high prevalence for the three most recent cohorts (1971-80, 1981-90, 1991-2001).
Conclusion: There were strong cohort and period effects in trends in the use of psychedelic and ecstasy.
Comparable studies
Other cross-sectional and survey studies on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Recreational MDMA use in Sydney: a profile of ‘Ecstasy’ users and their experiences with the drug Recreational Ecstasy users recruited via snowball peer network | 1992 | Cross-sectional survey | n = 100 |
| Reducedin vivobinding to the serotonin transporter in the cerebral cortex of MDMA (‘ecstasy’) users Male regular ecstasy users and well-matched controls | 1999 | Cross-sectional association study | n = 20 |
| Patterns of simultaneous polysubstance use in drug using university students Drug-using university students | 2006 | Cross-sectional survey | n = 149 |
| Patterns of recreational drug use at dance events in Edinburgh, Scotland Drug users at dance events in Edinburgh, Scotland, UK, aged 16-47, 80% between 18 and... | 2001 | Cross-sectional survey | n = 122 |
| Acute, sub‐acute and long‐term subjective consequences of ‘ecstasy’ (MDMA) consumption in 430 regular users Regular MDMA users | 2003 | Cross-sectional study | n = 466 |
Citations in the library
Cited by 6
- Reduced death anxiety as a mediator of the relationship between acute subjective effects of psychedelics and improved subjective well-being Death Studies February 2, 2023
- Cognitive functioning associated with acute and subacute effects of classic psychedelics and MDMA - a systematic review and meta-analysis. Scientific Reports June 26, 2024
- Prediction of hallucinogen persisting perception disorder and thought disturbance symptoms following psychedelic use. PNAS Nexus April 1, 2025
- Predictors Of Hallucinogen Persisting Perception Disorder Symptoms, Delusional Ideation And Magical Thinking Following Naturalistic Psychedelic Use November 15, 2022
- A Scoping Review of Research in Naturalistic Studies with Psychedelics. Journal of Psychoactive Drugs June 28, 2025
and 1 more in the library
Cites 10
- Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. Pharmacology & Therapeutics May 1, 2019
- Recreational MDMA use in Sydney: a profile of ‘Ecstasy’ users and their experiences with the drug British Journal of Addiction August 1, 1992
- MDMA enhances emotional empathy and prosocial behavior Social Cognitive and Affective Neuroscience October 4, 2013
- Distinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects Neuropsychopharmacology November 16, 2019
- Trends in LSD use among US adults: 2015-2018. Drug and Alcohol Dependence May 15, 2020
and 5 more in the library