New psychoactive substances: kratom, DMT, serotonergic hallucinogens, dissociative drugs. The mechanism of action, psychoactive effects
Andrey V. Antsyborov
Neurology Bulletin May 10, 2023 DOI: 10.17816/nb119895 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | DMT Serotonin |
| Key findings | The review identifies mitragynine (Kratom), dimethyltryptamine, a new generation of serotonergic hallucinogens, ketamine, and other dissociative substances as new psychoactive substances that have only been thoroughly studied in recent years, noting that such compounds can alter mental state, behavior, and social activity. |
Abstract
Through the times of human culture there was a desire of using various chemical compounds, obtained from both natural plant material and artificially synthesized, for recreational purposes. These substances can cause changes in the mental state, influence the human behavior, change social activity. The review is devoted to NPS, which have only been thoroughly studied in recent years. These substances include: mitragynine (Kratom), dimethyltryptamine, a new generation of serotonergic hallucinogens, ketamine, and other dissociative substances.
Comparable studies
Other narrative reviews on DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neuropharmacology of N,N-dimethyltryptamine | 2016 | Review | |
| N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function Humans and animals (general) | 2018 | Review | |
| Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Humans (pharmacokinetics) | 2010 | Review | |
| Pharmahuasca: Human Pharmacology of Oral DMT Plus Harmine Human self-experimenters | 1999 | Review | n = 8 |
| The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine | 1976 | Review |
Citations in the library
Cites 13
- Neuropharmacology of N,N-dimethyltryptamine Brain Research Bulletin April 30, 2016
- From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis 2014
- The Therapeutic Potentials of Ayahuasca: Possible Effects against Various Diseases of Civilization. Frontiers in Pharmacology March 2, 2016
- Pharmahuasca: Human Pharmacology of Oral DMT Plus Harmine Journal of Psychoactive Drugs April 1, 1999
- Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") Hallucinogens. Current Topics in Behavioral Neurosciences 2017
and 8 more in the library