The Theoretical Synthesis and in silico Modelling of Lysergic Acid Biscinnamylidene Amide from the Adduct Formation of d-Lysergic Acid Amide and Cinnamaldehyde
Victor Chiruta
Journal of Chemistry Studies March 5, 2022 DOI: 10.32996/jcs.2022.1.1.1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Key points | Proposes that a hypothetical lysergamide derivative, cinnamylidene-bislysergamide (LSBC), could form via a cinnamaldehyde adduct reaction, and argues that while this adduct formation is chemically plausible, evidence for psychedelic effects is weak. |
Abstract
Here is a theoretical synthesis for a cinnamaldehyde adduct formation of a hypothetically proposed lysergamide derivative named cinnamylidene-bislysergamide or lysergic acid biscinnamylidene amide (LSBC). This lysergamide name and abbreviation is in keeping with names of other lysergamide derivatives, such as d-lysergic acid amine (LSA), lysergic acid 2-butyl amide (LSB), lysergic acid diethylamide (LSD), d-lysergic acid α-hydroxyethylamide (LSH), lysergic acid methylisopropylamide (LSMIP), and lysergic acid 3-pentyl amide (LSP). Lysergamides are generally psychedelic in nature. The evidence for LSBC adduct formation is plausible, but the evidence supporting its psychedelic effects is weak.