Psychedelics and the Autonomic Nervous System: A Perspective on Their Interplay and Therapeutic Potential.
Hong-Yuan Li, Hongshuang Wang, Xiao-Hui Wang
ACS Pharmacology & Translational Science February 18, 2025 DOI: 10.1021/acsptsci.5c00005 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary Peer reviewed |
|---|---|
| Key points | Argues that psychedelics interact with the autonomic nervous system in ways that remain poorly understood, particularly regarding sympathetic and parasympathetic modulation, and proposes a research framework to clarify how these interactions influence cardiovascular health and therapeutic outcomes. |
Abstract
Psychedelics, known for their therapeutic potential in psychiatric disorders, interact with the autonomic nervous system in ways that are not well understood. This viewpoint examines the complex relationships between psychedelics and autonomic functions, focusing on sympathetic and parasympathetic modulation. We propose a research framework to elucidate how these interactions influence cardiovascular health and contribute to therapeutic outcomes.
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- The therapeutic potential of ayahuasca in depression, generalized anxiety, and substance use disorders: modulation of the depressive burden in a longitudinal study. Frontiers in Psychiatry 2026
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