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Impact of Developmental Stage on Responses to a School-Based Mindfulness Intervention

Michiko Ashitani, Yasushi Ito, Kazumi Yamamoto

Mindfulness February 26, 2026 DOI: 10.1007/s12671-026-02792-z (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Observational comparison of two age groups within a single-arm feasibility study Randomized Peer reviewed
Sample size 143
Population Japanese adolescents aged 12–17; 74 junior high students (12–14) and 69 senior high students (15–17)
Duration 10-week program; follow-up 2 months after intervention
Measures Center for Epidemiologic Studies Depression Scale (CES-D), Warwick–Edinburgh Mental Wellbeing Scale (WEMWBS), Strengths and Difficulties Questionnaire (SDQ), Profile of Mood States, Second Edition (POMS2)
Topics Meditation
Key findings Senior high participants showed significant improvements on all measures after the .b program, while junior high participants did not, with between-group differences statistically significant or marginally significant. No depressive symptom worsening occurred in either group. The authors propose that developmental stage may explain divergent UK feasibility study and MYRIAD trial results.

Abstract

Objectives: The .b (“dot be”) mindfulness program aims to reduce both internalizing and externalizing risks and to enhance well-being among adolescents. A UK-based feasibility study (FS) reported significant improvements in depressive symptoms, stress, and well-being, whereas a large-scale randomized controlled trial—the UK-based MYRIAD study (MS) found no improvements and even some negative outcomes. To assess whether developmental stage might play an explanatory role in these discrepancies, we evaluated and compared the responses to .b between two groups of Japanese adolescents, ages 12–14 and 15–17 years.

Method: A total of 143 Japanese students, 74 in junior high (JH, ages 12–14) and 69 in senior high (SH, ages 15–17), participated in the 10-week .b. Participants completed questionnaires at baseline, post-intervention, and 2 months later. Measures included the Center for Epidemiologic Studies Depression Scale (CES-D), the Warwick–Edinburgh Mental Wellbeing Scale (WEMWBS), the Strengths and Difficulties Questionnaire (SDQ), and the Profile of Mood States, Second Edition (POMS2).

Results: The SH group showed significant improvements across all measures, while the JH group did not. The differences in the degree of improvement between the two groups were statistically significant or marginally significant. No worsening of depressive symptoms was observed in either group, including among younger or high-risk subgroups.

Conclusions: These findings suggest that the response to .b may vary depending on the developmental stage of the participants, which may help explain the differing results between the FS and MS in the UK.

Comparable studies

Other non-randomized and open-label trials on meditation, most cited first.

Study Year Design Participants
Mindfulness-Based Stress Reduction in Relation to Quality of Life, Mood, Symptoms of Stress, and Immune Parameters in Breast and Prostate Cancer Outpatients Early-stage breast and prostate cancer patients 2003 Pre-post intervention study n = 59
Exploring self‐compassion and empathy in the context of mindfulness‐based stress reduction (MBSR) Community sample 2010 Pre-post intervention study
Mindfulness-Based Stress Reduction Lowers Psychological Distress In Medical Students Second-year medical students 2003 Prospective nonrandomized cohort-controlled study n = 302
Intensive meditation training, immune cell telomerase activity, and psychological mediators. Retreat participants and matched controls 2011 Controlled trial with wait-list control group n = 60
The Effectiveness of Mindfulness Training for Children with ADHD and Mindful Parenting for their Parents Children aged 8-12 with ADHD and their parents 2011 Within-group waitlist controlled trial n = 22

Citations in the library

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