Clinical Diagnosis and Management of Gradual Onset Cannabis-Induced Psychosis Following the Consumption of Delta-8-Tetrahydrocannabinol
Edward E. Denton, Sophia S. Jung, C. A. I. Ventura
Cureus March 1, 2024 DOI: 10.7759/cureus.55464 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A male patient in his 20s presenting to the emergency department after ingesting a delta-8-tetrahydrocannabinol gummy |
| Intervention | Aripiprazole |
| Dose | 10 mg of aripiprazole daily |
| Duration | Recovery within four days of starting treatment |
| Topics | Cannabis |
| Key findings | The authors report that a man in his 20s developed derealization two days after ingesting a delta-8-THC gummy, then religious-themed psychosis two days after emergency department discharge, and appeared to recover within four days of starting 10 mg daily aripiprazole. They present the case as adding to the limited literature on cannabis-induced psychosis and its emergency department diagnosis and treatment. |
Abstract
Cannabis-induced psychosis (CIP) is an increasingly acknowledged psychiatric phenomenon observed in vulnerable patients exposed to cannabis. This brief case report details a male patient in his 20s, who presents to the ED with derealization two days after ingesting a gummy worm containing delta-8-tetrahydrocannabinol (Δ8-THC). Two days post-ED discharge, the patient gradually developed symptoms of religious-themed psychosis and was prescribed 10 mg of aripiprazole daily. The patient seemingly recovered within four days of starting treatment. This paper contributes to the limited literature pertaining to CIP and discusses implications for diagnostics and treatment in the ED setting.
Comparable studies
Other case reports and case series on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Hallucinogen persisting perception disorder after psilocybin consumption: a case study 18-year-old man with HPPD after mixed psilocybin and cannabis intoxication | 2005 | Case study | n = 1 |
| Cannabis‐induced Koro in Americans American men aged 22-26 with years of cannabis experience who reported negative... | 2001 | Case series | n = 3 |
| “Hallucinations” Following Acute Cannabis Dosing: A Case Report and Comparison to Other Hallucinogenic Drugs Healthy 30-year-old male | 2018 | Case study | n = 1 |
| Hallucinogen persisting perception disorder: A literature review and three case reports Patients with hallucinogen persisting perception disorder | 2018 | Case series | n = 3 |
| Cannabis Psychosis in Young Psychiatric Inpatients Consecutive psychiatric hospital admissions of patients aged 35 and under | 1986 | Case study | n = 25 |
Citations in the library
Cites 6
- Delta-8 tetrahydrocannabinol: a scoping review and commentary. Addiction June 1, 2023
- Cannabis induced psychosis: a systematic review on the role of genetic polymorphisms. Pharmacological Research May 1, 2022
- Risks and Benefits of Cannabis and Cannabinoids in Psychiatry. American Journal of Psychiatry February 2022
- Psychiatric and Medical Management of Marijuana Intoxication in the Emergency Department Western Journal of Emergency Medicine May 7, 2015
- Induction of psychosis by Δ9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processing. Archives of General Psychiatry January 2012
and 1 more in the library