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Novel N‑Substituted Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders.

Ram W. Sabnis

ACS Medicinal Chemistry Letters June 16, 2025 DOI: 10.1021/acsmedchemlett.5c00346 (opens in new tab)

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Characteristics Peer reviewed
Topics Serotonin
Key points The document discloses novel N-substituted indole derivatives as serotonergic psychedelic agents and proposes their use in pharmaceutical compositions for treating psychosis, mental illness, and central nervous system disorders, along with methods for their preparation.

Abstract

Provided herein are novel N-substituted indole derivatives as serotonergic psychedelic agents, pharmaceutical compositions, use of such compounds in treating psychosis, mental illness and central nervous system (CNS) disorders, and processes for preparing such compounds.

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