Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects.
A W Zuardi, I Shirakawa, E Finkelfarb, I G Karniol
Psychopharmacology 1982 DOI: 10.1007/bf00432554 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Double-blind experiment Peer reviewed |
|---|---|
| Sample size | 8 |
| Population | Normal volunteers |
| Interventions | delta 9-THC cannabidiol (CBD) placebo diazepam |
| Dose | 0.5 mg/kg delta 9-THC, 1 mg/kg CBD, 10 mg diazepam |
| Topics | Anxiety Cannabis CBD |
| Key findings | CBD blocked the anxiety provoked by delta 9-THC, but also reduced marijuana-like and other subjective effects of delta 9-THC. The antagonism did not appear to be a general block of delta 9-THC effects, since pulse-rate measurements were unchanged. The authors suggest CBD's opposite effects may be involved in the antagonism between the two cannabinoids. |
Abstract
The object of the experiment was to verify whether cannabidiol (CBD) reduces the anxiety provoked by delta 9-THC in normal volunteers, and whether this effect occurs by a general block of the action of delta 9-THC or by a specific anxiolytic effect. Appropriate measurements and scales were utilized and the eight volunteers received, the following treatments in a double-blind procedure: 0.5 mg/kg delta 9-THC, 1 mg/kg CBD, a mixture containing 0.5 mg/kg delta 9-THC and 1 mg/kg CBD and placebo and diazepam (10 mg) as controls. Each volunteer received the treatments in a different sequence. It was verified that CBD blocks the anxiety provoked by delta 9-THC, however this effect also extended to marihuana-like effects and to other subjective alterations induced by delta 9-THC. This antagonism does not appear to be caused by a general block of delta 9-THC effects, since no change was detected in the pulse-rate measurements. Several further effects were observed typical of CBD and of an opposite nature to those of delta 9-THC. These results suggest that the effects of CBD, as opposed to those of delta 9-THC, might be involved in the antagonism of effects between the two cannabinoids.
Comparable studies
Other randomized controlled trials on cannabis for anxiety, most cited first.
Citations in the library
Cited by 78
- Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment Journal of Psychopharmacology October 5, 2012
- Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing Archives of General Psychiatry 2009
- Beyond THC: The New Generation of Cannabinoid Designer Drugs Frontiers in Behavioral Neuroscience 2011
- Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug Brazilian Journal of Medical and Biological Research April 1, 2006
- Traditional marijuana, high‐potency cannabis and synthetic cannabinoids: increasing risk for psychosis World Psychiatry September 22, 2016
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