Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists.
M. Bowers, J. B. Morton
Progress in Neuro-Psychopharmacology and Biological Psychiatry March 1, 1992 DOI: 10.1016/0278-5846(92)90072-m (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Male rats |
| Interventions | Diazepam MK-801 saline |
| Key points | Diazepam lowered the MK-801-induced increase in homovanillic acid in the caudate, olfactory tubercle, and prefrontal cortex of male rats, mirroring earlier findings with phencyclidine. The authors propose that benzodiazepine receptors may modify dopaminergic function at PCP receptors affecting dopamine neurotransmission. |
Abstract
1. Male rats were injected with either saline, diazepam, MK-801, or diazepam plus MK-801. 2. In previous work with phencyclidine (PCP), diazepam significantly reduced the increase in homovanillic acid (HVA) in olfactory tubercle and prefrontal cortex. 3. Diazepam also lowered the HVA increase following MK-801 in caudate, olfactory tubercle, and prefrontal cortex. 4. Benzodiazepine receptors may modify dopaminergic function at PCP receptors that affect dopamine neurotransmission.
Citations in the library
Cited by 2
- The effects of single and repeated phencyclidine administration on [125I] iomazenil binding in the rat brain. Neurochemistry International September 1996
- Differential effects of phencyclidine and methamphetamine on dopamine metabolism in rat frontal cortex and striatum as revealed by in vivo dialysis. Synapse April 1996