NMDA-coupled and uncoupled forms of the PCP receptor: preliminary in vivo evidence for PCP receptor subtypes.
Progress in Neuro-Psychopharmacology and Biological Psychiatry 1989 DOI: 10.1016/0278-5846(89)90140-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Key findings | PCP receptor agonists increase mesocortical dopamine metabolism and release in a stereospecific, dose- and time-dependent manner, involving PCP receptors in the ventral tegmental area and cortical terminals. Unlike cerebellar cGMP effects, this action is not shared by competitive NMDA antagonists, sigma ligands, or NMDA agonists. The authors suggest the PCP receptor population modulating mesocortical dopamine neurons is not coupled to NMDA receptors. |
Abstract
1. As reported for many other PCP receptor actions, the pharmacological profile of PCP receptor agonists and NMDA receptor antagonists were similar with regard to their effects on cerebellar cGMP levels in vivo. 2. PCP receptor agonists act to increase mesocortical dopamine (DA) metabolism and release. 3. This receptor action is stereospecific and is both dose- and time-dependent. 4. The actions of PCP on DA metabolism appear to involve PCP receptors both in the ventral tegmental area (VTA) and the cortical nerve terminal regions. 5. In contrast to many other systems which have been studied, competitive NMDA antagonists do not act in a manner similar to PCP agonists, with regard to mesocortical DA metabolism. 6. Sigma receptor ligands and NMDA agonists also do not alter mesocortical DA metabolism. 7. These data suggest that the PCP receptor population which modulates mesocortical dopaminergic neurons is not coupled to NMDA receptors.
Citations in the library
Cited by 3
- Sigma binding states in the brain; An emerging concept for multiple sites and their relevance for psychiatric disorders Life Sciences 1990
- Contrasting Neurochemical Interactions of Tiletamine, a Potent Phencyclidine (PCP) Receptor Ligand, with the N ‐Methyl‐D‐Aspartate‐Coupled and ‐Uncoupled PCP Recognition Sites Journal of Neurochemistry March 1, 1991
- Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists. Progress in Neuro-Psychopharmacology and Biological Psychiatry March 1, 1992
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