Phencyclidine-like behavioral effects of 2-methyl-3,3-diphenyl-3-propanolamine (2-MDP).
A H Tang, A A Cangelosi, R A Code, S R Franklin
Pharmacology, Biochemistry, and Behavior February 1984 DOI: 10.1016/0091-3057(84)90244-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Rats trained to discriminate PCP from saline, rats trained to avoid shocks in an automated Y-maze, and rhesus monkeys |
| Interventions | 2-Methyl-3 3-diphenyl-3-propanolamine (2-MDP) |
| Dose | 1 mg/kg (PCP training dose) |
| Key points | 2-MDP produced PCP-like effects in animals, sharing PCP's discriminative stimulus properties in rats, disrupting brightness discrimination and stimulating locomotion at higher doses, and producing surgical anesthesia in rhesus monkeys when given intravenously. These effects were limited to the levo-isomer; the dextro-isomer was inactive or produced opposite effects depending on the test. |
Abstract
2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) produced effects in animals similar to those produced by the dissociative anesthetics such as phencyclidine (PCP). Specifically, it shared the discriminative stimulus properties of PCP in rats trained to discriminate PCP (1 mg/kg) from saline; at higher doses, it disrupted brightness discrimination and stimulated locomotor activities in rats trained to avoid shocks in an automated Y-maze; and it produced surgical anesthesia when injected IV to rhesus monkeys. These pharmacological activities were observed only with the levo-isomer of 2-MDP. The dextro-isomer was either inactive or produced opposite effects, depending on the tests. Among several related diphenylpropylamines, 2-MDP represents the optimal structure for potency of PCP-like effects since changes in the amino, 2-methyl and 3-hydroxy groups reduced the potencies of the PCP-like discriminative properties.