Cannabis, atropine, and temporal information processing.
R E Hicks, C T Gualtieri, J P Mayo, M Perez-Reyes
Neuropsychobiology 1984 DOI: 10.1159/000118144 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Interventions | (-)-delta 9-tetrahydrocannabinol (THC) atropine sulfate saline |
| Topics | Cannabis |
| Key findings | THC increased the subjective time rate in both duration-production and subjective-second-counting tasks, whereas atropine had no effect, indicating that THC alters the ongoing experience of time and that reduced central acetylcholine activity is not a sufficient explanation for this effect. |
Abstract
In experiment 1, subjects judged time by duration production under no-counting instructions. The productions were made following intravenous injection of atropine sulfate or saline, and after smoking cigarettes with and without (-)-delta 9-tetrahydrocannabinol (THC). THC increased the subjective time rate (STR); i.e., the rate at which subjective time passes relative to clock time, whereas atropine had no effect on STR. Thus, reduction in central acetylcholine activity is not a sufficient explanation of THC's effect on STR. Experiment 2 replicated the THC effect on STR when subjects were counting subjective seconds. This result indicates that THC affects the experience of time as it is passing, and not solely the memory for duration experience after a time period.
Comparable studies
Other randomized controlled trials on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment Healthy participants | 2012 | Randomized controlled trial | n = 48 |
| Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing Healthy, English-native, right-handed men who had used cannabis 15 times or less in... | 2009 | Double-blind, randomized, placebo-controlled crossover trial | n = 15 |
| Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers Healthy male subjects | 2012 | Randomized controlled trial | n = 16 |
| Modulation of Mediotemporal and Ventrostriatal Function in Humans by Δ9-Tetrahydrocannabinol Healthy, native English-speaking, right-handed men of white race/ethnicity who had used... | 2009 | Randomized controlled trial | n = 15 |
| Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition Healthy volunteers with a history of light cannabis use | 2019 | Randomized, double-blind, within-subjects crossover | n = 14 |
Citations in the library
Cited by 6
- Gone to Pot – A Review of the Association between Cannabis and Psychosis Frontiers in Psychiatry May 22, 2014
- Clinical, Cognitive, and Neurobiological Correlates of Impaired Timing Abilities Associate to Cannabis Use: a Systematic Review International Journal of Mental Health and Addiction August 29, 2023
- Acute Effects of THC on Time Perception in Frequent and Infrequent Cannabis Users Psychopharmacology November 24, 2012
- Effects of marijuana on temporal discriminations in humans. Behavioural Pharmacology March 2006
- Impaired information processing triggers altered states of consciousness. Medical Hypotheses April 1, 2002
and 1 more in the library