Interactions between delta 9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons.
A J Hiltunen, Torbjörn U C Järbe
Neuropharmacology February 1986 DOI: 10.1016/0028-3908(86)90034-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats and pigeons trained to discriminate delta 9-THC from its absence |
| Interventions | delta 9-THC cannabidiol 3-PPP |
| Dose | 0.56 mg/kg (pigeons, i.m.); 3.0 mg/kg (rats, training); 1 mg/kg delta 9-THC (rats, i.p.); 0.10–0.56 mg/kg delta 9-THC (pigeons); cannabidiol 30.0 mg/kg (i.p., rats) and 17.5 mg/kg (i.m., pigeons) |
| Topics | Cannabis CBD |
| Key findings | In pigeons, delta 9-THC-appropriate responding was below 50% at 0.5 and 9 hours after injection but above 90% at 1.5 and 4.5 hours. Cannabidiol prolonged the cue effects of 1 mg/kg delta 9-THC in rats but did not change the time-effect curve in pigeons, and 3-PPP did not induce THC-appropriate responding in rats. |
Abstract
Animals (rats and pigeons) were trained to discriminate between the presence and absence of delta 9-THC; the training doses were, respectively: 0.56 mg/kg (pigeons) and 3.0 mg/kg (rats). Once the drug discrimination was mastered, the pigeons were tested repeatedly after a single intramuscular (i.m.) injection of delta 9-THC (0.56 mg/kg) at the following intervals 0.5, 1.5, 4.5 and 9 hr after the injection. These results were compared with data from a separate procedure, i.e. where the various intervals after injection were examined only once per injection and both procedures yielded essentially the same outcome. Thus, less than 50% appropriate responding to THC was observed at 0.5 and 9 hr after injection, whereas greater than 90% responding to THC occurred at 1.5 and 4.5 hr. The two procedures have previously been compared in rats (Järbe, Swedberg and Mechoulam, 1981). The repeated tests procedure was then used to evaluate combinations of delta 9-THC and cannabidiol in both species. Cannabidiol prolonged the cue effects of 1 mg/kg of delta 9-THC (intraperitoneal route of administration) in rats but did not change the time-effect curve for delta 9-THC in pigeons (dose range examined: 0.10--0.56 mg/kg); the challenge doses of cannabidiol were, respectively: 30.0 mg/kg (i.p.) and 17.5 mg/kg (i.m.). The rate of responding did not differ in tests with combinations of delta 9-THC and cannabidiol as compared to delta 9-THC given alone in pigeons. Subcutaneously administered 3-PPP, a dopamine pre-synaptic blocker, did not induce responding appropriate for delta 9-THC in rats.
Comparable studies
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Citations in the library
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- A critical assessment of the abuse, dependence and associated safety risks of naturally occurring and synthetic cannabinoids. Frontiers in Psychiatry 2024
- Evaluation of the Modulatory Effects of Minor Cannabinoids and Terpenes on Delta-9-Tetrahydrocannabinol Discrimination in Rats. Cannabis and Cannabinoid Research September 2023
- Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol. Neuropsychopharmacology January 2018
- Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol. Drug and Alcohol Dependence April 1, 2008
and 1 more in the library
Cites 6
- Characteristics of tetrahydrocannabinol (THC)-produced discrimination in rats Psychopharmacology 1976
- Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology 1982
- LDS-25 as a discriminative stimulus for response selection by pigeons. Pharmacology, Biochemistry, and Behavior October 1980
- Interactions in man of delta-9-tetrahydrocannabinol. II. Cannabinol and cannabidiol. Clinical Pharmacology & Therapeutics July 1975
- Delta 9-tetrahydrocannabinol produced discrimination in pigeons. Pharmacology, Biochemistry, and Behavior 1975
and 1 more in the library