Electroencephalographic and behavioral alterations produced by delta-1-tetrahydrocannabinol.
C H Hockman, R G Perrin, H Kalant
Science May 28, 1971 DOI: 10.1126/science.172.3986.968 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Cats with indwelling electrodes |
| Intervention | Delta(l)-tetrahydrocannabinol |
| Dose | small doses |
| Measures | electroencephalogram |
| Topics | Cannabis |
| Key findings | Small doses of Delta(l)-tetrahydrocannabinol disrupted the electroencephalogram and behavior of cats with implanted electrodes, producing a high-voltage slow-wave electroencephalogram in awake, moving animals. The authors note that similar electroencephalogram changes occur in cats given other drugs known to cause hallucinogenic states in humans. |
Abstract
The administration of small doses of Delta(l)-tetrahydrocannabinol to cats with indwelling electrodes produced a disruption of both the electroencephalogram and behavior. Some of these alterations, including the appearance of a high-voltage slow wave electroencephalogram in the awake and moving animal, have been observed in cats that had been administered other drugs known to cause hallucinogenic states in man.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.