Electroencephalographic and behavioral alterations produced by delta-1-tetrahydrocannabinol.
C H Hockman, R G Perrin, H Kalant
Science (New York, N.Y.) May 28, 1971 DOI: 10.1126/science.172.3986.968 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Cats with indwelling electrodes |
| Intervention | Delta(l)-tetrahydrocannabinol |
| Dose | small doses |
| Measures | electroencephalogram |
| Topics | Cannabis |
| Key findings | Small doses of Delta(l)-tetrahydrocannabinol disrupted the electroencephalogram and behavior of cats with implanted electrodes, producing a high-voltage slow-wave electroencephalogram in awake, moving animals. The authors note that similar electroencephalogram changes occur in cats given other drugs known to cause hallucinogenic states in humans. |
Abstract
The administration of small doses of Delta(l)-tetrahydrocannabinol to cats with indwelling electrodes produced a disruption of both the electroencephalogram and behavior. Some of these alterations, including the appearance of a high-voltage slow wave electroencephalogram in the awake and moving animal, have been observed in cats that had been administered other drugs known to cause hallucinogenic states in man.