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Effects of acute marijuana smoking on pulse rate and mood states in women.

B W Lex, J H Mendelson, S Bavli, K Harvey, N K Mello

Psychopharmacology 1984 DOI: 10.1007/bf00427443 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Double-blind placebo-controlled study Peer reviewed
Sample size 28
Population Adult female volunteers
Intervention Marijuana cigarette (1.8% THC)
Dose 1.8% THC
Measures POMS confusion factor
Topics Cannabis
Key points Marijuana smoking (1.8% THC) significantly increased pulse rate, subjective intoxication, and POMS confusion scores, but these effects did not differ significantly across menstrual cycle phases. Women with a history of intermittent marijuana use (five or fewer times weekly) had significantly greater and longer-lasting increases in pulse rate, intoxication, and confusion than those with a history of regular use (six or more times weekly).

Abstract

The effects of marijuana cigarette (1.8% THC) smoking on pulse rate and mood were studied under double-blind placebo-controlled conditions in 28 adult female volunteers during the follicular, luteal, and ovulatory phases of the menstrual cycle. Statistically significant increases in pulse rate, subjective levels of intoxication, and the POMS confusion factor occurred after marijuana smoking. However, no statistically significant differences for any measure were observed following marijuana smoking as a function of menstrual cycle phase. Subjects with a past history of intermittent marijuana use (five or less times weekly) had significantly higher pulse rates, subjective levels of intoxication, and POMS confusion factor scores than did subjects with a past history of regular (six or more times weekly) marijuana use. Persistence of marijuana-induced changes in pulse rate, intoxication, and confusion were also of longer duration for subjects with a past history of intermittent marijuana smoking. The influence of past history of marijuana use on marijuana-induced alterations in pulse rate, intoxication, and mood for females appears to be similar to males. These similarities are not attenuated as a function of the menstrual-cycle phase of females.

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Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers Healthy male subjects 2012 Randomized controlled trial n = 16
Modulation of Mediotemporal and Ventrostriatal Function in Humans by Δ9-Tetrahydrocannabinol Healthy, native English-speaking, right-handed men of white race/ethnicity who had used... 2009 Randomized controlled trial n = 15
Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition Healthy volunteers with a history of light cannabis use 2019 Randomized, double-blind, within-subjects crossover n = 14

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