The effect of MDA and MDMA ("Ecstasy") isomers in combination with pirenpirone on operant responding in mice.
John A. Rosecrans, Richard A Glennon
Pharmacology, Biochemistry, and Behavior September 1987 DOI: 10.1016/0091-3057(87)90008-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 27 |
| Population | Mice trained to bar-press for a liquid food reinforcement |
| Interventions | R(-)-MDA S(+)-MDA S(+)-MDMA pirenpirone saline |
| Topics | MDMA |
| Key findings | Pirenpirone significantly attenuated the behaviorally disruptive effects of R(-)-MDA but not those of S(+)-MDA, R(-)-MDA, or S(+)-MDMA. The authors suggest that R(-)-MDA may produce its behavioral disruption via an action on 5-HT-2 receptors, consistent with prior research. |
Abstract
The behaviorally disruptive effects of the optical isomers of 1-(3,4-methylenedioxyphenyl-2-aminopropane) (MDA) and its N-methyl derivative (MDMA) were evaluated in 27 mice trained to bar-press for a liquid food reinforcement. In addition, a second study was conducted in which mice were pretreated with either saline or the 5-HT-2 antagonist, pirenpirone, prior to the administration of either MDMA or MDA using the same behavioral procedure. The results indicated that the behaviorally disruptive effects produced only by R(-)-MDA, but not those of S(+)-MDA, R(-)-MDA, nor of S(+)-MDMA, were significantly attenuated by pirenpirone. These findings support previous research findings which indicate that this isomer may be producing its behaviorally disruptive effects via an action on 5-HT-2 receptors.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 13
- MDMA (3,4-Methylenedioxymethamphetamine) Analogues as Tools to Characterize MDMA-Like Effects: An Approach to Understand Entactogen Pharmacology Current Neuropharmacology August 1, 2013
- History of MDMA Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA 1990
- MDMA and memory: the acute and chronic effects of MDMA in pigeons performing under a delayed-matching-to-sample procedure Psychopharmacology February 1, 1993
- Behavioral profiles in rats distinguish among "ecstasy," methamphetamine and 2,5-dimethoxy-4-iodoamphetamine: Mixed effects for "ecstasy" analogues. Behavioral Neuroscience October 1, 2010
- α-Ethyltryptamine: A Ratiocinatory Review of a Forgotten Antidepressant. ACS Pharmacology & Translational Science December 8, 2023
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