Direct comparison of hallucinogenic phenethylamines and D-amphetamine on dorsal raphe neurons.
European Journal of Pharmacology April 1, 1986 DOI: 10.1016/0014-2999(86)90420-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal electrophysiology study Peer reviewed |
|---|---|
| Population | Rat dorsal raphe neurons |
| Interventions | 2 5-dimethoxy-4-methylamphetamine (DOM) mescaline D-amphetamine |
| Key points | Direct microiontophoretic application of DOM and mescaline had little or no effect on rat dorsal raphe neuron firing, while D-amphetamine clearly inhibited it. The authors suggest that the inhibitory effects seen after intravenous phenethylamine administration are largely indirect, not mediated directly on the serotonergic cell. |
Abstract
We compared the effects of the hallucinogens 2,5-dimethoxy-4-methylamphetamine (DOM), mescaline and the simulant D-amphetamine, applied by microiontophoresis to rat dorsal raphe (DR) units. DR neuron firing rate was relatively insensitive to DOM and unaffected by mescaline, but was clearly inhibited by D-amphetamine. Intravenous DOM usually inhibited, but this effect was correlated with blood pressure changes; i.v. D-amphetamine produced inconsistent responses. These results suggest that most of the effects seen on i.v. administration of phenethylamines are not mediated directly on the serotonergic cell.