Effects of hallucinogenic drugs on serotonergic neuronal systems.
R B McCall
Pharmacology, Biochemistry, and Behavior February 1986 DOI: 10.1016/0091-3057(86)90366-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Topics | Serotonin |
| Key points | Argues that the suppression of dorsal raphe serotonin neuron firing and the relative insensitivity of forebrain serotonergic neurons are insufficient to explain hallucinogens' psychoactive effects, and proposes that sensitization of serotonin and norepinephrine receptors in the facial nucleus, described as common to all and specific to hallucinogens, may account for the altered perceptual reactivity these drugs produce. |
Abstract
Studies indicate that hallucinogens markedly suppress the discharge of serotonin containing neurons in the dorsal raphe nucleus. Forebrain neurons receiving a major serotonergic input are relatively insensitive to hallucinogens. These actions of hallucinogens are not sufficient to explain the psychoactive effects of these drugs. Evidence is presented to indicate that hallucinogens sensitize serotonin and norepinephrine receptors in the facial nucleus. This receptor sensitizing effect is common to all, and specific for, hallucinogens. It is suggested that a mechanism of receptor sensitization might account for the altered perceptual reactivity produced by hallucinogens.
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