LSD and other related hallucinogens elicit myoclonic jumping behavior in the guinea pig.
P Carvey, P Nausieda, R Weertz, H Klawans
Progress in Neuro-Psychopharmacology and Biological Psychiatry 1989 DOI: 10.1016/0278-5846(89)90017-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal behavioral pharmacology study Peer reviewed |
|---|---|
| Population | Guinea pigs |
| Interventions | LSD mescaline DOM TMA DMA 5-Me-ODMT Brom-LSD |
| Topics | LSD |
| Key points | LSD produced dose-dependent "myoclonic-like" behavior in guinea pigs that showed rapid tolerance and cross-tolerance with mescaline; mescaline, DOM, TMA, DMA, and 5-Me-ODMT also produced dose-dependent myoclonus with potency ratios approximating human hallucinogenic activity, while Brom-LSD did not. The authors propose the guinea pig may be a useful model for studying hallucinogenic compounds. |
Abstract
1. We evaluated the behavioral response of guinea pigs to hallucinogenic agents in order to characterize the response of this species to a variety of known hallucinogenic drugs. 2. The systemic injection of LSD in the guinea pig elicited a "myoclonic-like" response the frequency of which was dose-dependent. This behavior exhibited rapid tolerance which was more prominent at higher doses. 3. Subacute mescaline pretreatment reduced the myoclonic response to LSD suggesting cross-tolerance. 4. Mescaline, DOM, TMA, DMA and 5 Me-ODMT also elicited myoclonus in a dose-dependent manner and in potency ratios which approximate the human experience for hallucinogenic activity. 5. Brom-LSD failed to induce myoclonus. 6. Since the myoclonic response of the guinea pig shares a number of pharmacologic characteristics with the human hallucinogenic event, this species may be useful in the study of hallucinogenic compounds.
Citations in the library
Cites 3
- A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists. British Journal of Pharmacology July 1, 1981
- An Animal Behavior Model for Studying the Actions of LSD and Related Hallucinogens Science November 12, 1976
- BEHAVIOURAL CHANGES INDUCED BY N,N‐DIMETHYLTRYPTAMINE IN RODENTS British Journal of Pharmacology May 1, 1980