The effects of (+)-SKF10047 and ketamine hydrochloride on stereotyped behaviour, locomotor activity and ataxia in guinea pig.
A H Jerram, P F Smith, C L Darlington
European Journal of Pharmacology July 1, 1996 DOI: 10.1016/0014-2999(96)00267-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Guinea pigs |
| Intervention | ketamine hydrochloride |
| Dose | (+)-SKF10047: 2.5-10.0 mg/kg, i.p.; ketamine hydrochloride: 12.5 and 25.0 mg/kg, i.p. |
| Topics | Ketamine Esketamine |
| Keywords | Animals Guinea pigs Ataxia Phenazocine Receptors, sigma Receptors, n-methyl-d-aspartate Motor activity Stereotyped behavior Reaction time |
| Key findings | (+)-SKF10047 and ketamine did not produce significant stereotyped behavior or locomotor hyperactivity in guinea pigs at the doses tested. (+)-SKF10047 caused ataxia only at the highest dose (10 mg/kg), while ketamine caused ataxia and righting reflex impairment at the lower dose (12.5 mg/kg). |
Abstract
Although behavioural studies of the effects of (+/-)-N-allylnormetazocine ((+)-SKF10047) and ketamine hydrochloride have been conducted in many species, there are no data available on their effects in guinea pig. The aim of the present study was to provide an analysis of the effects of these drugs on stereotyped behaviour, locomotor activity, ataxia and righting reflex latency in guinea pigs. (+)-SKF10047 did not produce significant stereotyped behaviour nor locomotor hyperactivity at any of the doses tested (2.5-10.0 mg/kg, i.p). While righting reflex latency was not significantly affected, significant ataxia was produced at the highest (+)-SKF10047 dose used (i.e., 10 mg/kg). The results for ketamine hydrochloride were similar. Neither significant stereotyped behaviour nor locomotor hyperactivity were produced by ketamine at either dose used (12.5 and 25.0 mg/kg, i.p). However, at the lower dose (i.e., 12.5 mg/kg), significant ataxia and a significant impairment of the righting reflex were produced.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cites 5
- Recent advances in the phencyclidine model of schizophrenia American Journal of Psychiatry October 1, 1991
- Ketamine activates psychosis and alters limbic blood flow in schizophrenia Neuroreport April 1, 1995
- The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias. Brain research. Brain research reviews February 1, 1995
- Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science June 16, 1989
- Biochemical and behavioral effects of sigma and PCP ligands Synapse 1988