Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain by 1-piperonylpiperazine.
Kenji Hashimoto, H Maeda, Tsuyoshi Goromaru
European Journal of Pharmacology September 1, 1992 DOI: 10.1016/0926-6917(92)90027-a (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Male Wistar rats |
| Interventions | MDMA 6-nitroquipazine paroxetine 1-piperonylpiperazine N alpha-dimethylpiperonylamine |
| Dose | MDMA 10 mg/kg; 6-nitroquipazine 10 mg/kg; paroxetine 10 mg/kg; 1-piperonylpiperazine 20 mg/kg; N,alpha-dimethylpiperonylamine 20 mg/kg |
| Topics | Serotonin MDMA |
| Keywords | Brain Animals Rats, wistar N-methyl-3,4-methylenedioxyamphetamine Hydroxyindoleacetic acid Piperazines Quipazine Serotonin antagonists Injections, intraperitoneal Male |
| Key points | Coadministration of 6-nitroquipazine, paroxetine, or 1-piperonylpiperazine significantly attenuated MDMA-induced reductions in serotonergic parameters in the rat cerebral cortex, while N,alpha-dimethylpiperonylamine did not. The authors suggest that 1-piperonylpiperazine may protect against MDMA-induced neurotoxicity through effects other than 5-HT uptake inhibition. |
Abstract
The effects of 1-piperonylpiperazine and N,alpha-dimethylpiperonylamine, which are weak inhibitors for [3H]5-hydroxytryptamine (5-HT) uptake, on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity were examined. The reductions of serotonergic parameters in the rat cerebral cortex produced by multiple administration of MDMA (10 mg/kg) were attenuated significantly by coadministration of 6-nitroquipazine (10 mg/kg), paroxetine (10 mg/kg) or 1-piperonylpiperazine (20 mg/kg), but not by N,alpha-dimethylpiperonylamine (20 mg/kg). The present data suggest that 1-piperonylpiperazine might inhibit the MDMA-induced neurotoxicity by effect(s) other than 5-HT uptake inhibition.
Citations in the library
Cited by 3
- Effects of benzylpiperazine derivatives on the acute effects of 3,4-methylenedioxymethamphetamine in rat brain. Neuroscience Letters April 1, 1993
- Drug effects on distribution of [3H]3,4-methylenedioxymethamphetamine in mice. European Journal of Pharmacology April 1, 1993
- Effects of benzylpiperazine derivatives on the neurotoxicity of 3,4-methylenedioxymethamphetamine in rat brain. Brain Research September 1, 1992
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