Hyperaemia in rat neocortex produced by acute exposure to methylenedioxymethamphetamine.
P A Kelly, I M Ritchie, M Sangra, M J Cursham, E M Dickson, B Kelly, F P Neilson, M J Reidy, M C Stevens
Brain Research December 1, 1994 DOI: 10.1016/0006-8993(94)91354-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational animal study Peer reviewed |
|---|---|
| Population | Male Sprague-Dawley rats |
| Intervention | Methylenedioxymethamphetamine |
| Dose | 5 mg/kg, i.v. |
| Measures | [14C]iodoantipyrine, [14C]2-deoxyglucose |
| Topics | MDMA |
| Keywords | Brain Cerebral cortex Animals Rats, sprague-dawley Hyperemia N-methyl-3,4-methylenedioxyamphetamine Glucose Motor activity Tissue distribution Blood pressure Cerebrovascular circulation Time factors Male |
| Key findings | Methylenedioxymethamphetamine (5 mg/kg i.v.) produced marked hyperperfusion in rat frontal and parietal cortex without changing glucose utilization, whereas blood flow and glucose metabolism were coupled in control rats. The authors suggest the drug has the potential to disrupt cerebrovascular control. |
Abstract
Cerebral blood flow and glucose utilization were measured in rat neocortex, hippocampus and striatum following methylenedioxymethamphetamine injection (5 mg/kg, i.v.), using the tracers [14C]iodoantipyrine and [14C]2-deoxyglucose, respectively. In control rats, blood flow was coupled to glucose metabolism, but in methylenedioxymethamphetamine-treated rats, marked hyperperfusion was measured in frontal and parietal cortex with no change in glucose use. This suggests that methylenedioxymethamphetamine has the potential to disrupt cerebrovascular control.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 5
- Brain hyperthermia induced by MDMA (‘ecstasy’): modulation by environmental conditions European Journal of Neuroscience July 1, 2004
- Investigation of the prejunctional α2‐adrenoceptor mediated actions of MDMA in rat atrium and vas deferens British Journal of Pharmacology November 1, 1999
- Vascular actions of MDMA involve α1 and α2‐adrenoceptors in the anaesthetized rat British Journal of Pharmacology June 1, 2001
- L-Tyrosine Contributes to (+)-3,4-Methylenedioxymethamphetamine-Induced Serotonin Depletions Journal of Neuroscience January 4, 2006
- Actions of amphetamine derivatives and cathinone at the noradrenaline transporter. European Journal of Pharmacology August 22, 2003
Cites 3
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- (±3,4-Methylenedioxymethamphetamine Selectively Damages Central Serotonergic Neurons in Nonhuman Primates JAMA July 1, 1988
- The Psychological and Physiological Effects of MDMA on Normal Volunteers Journal of Psychoactive Drugs October 1, 1986