Comparison of conditioned taste aversions produced by MDMA and d-amphetamine.
H Q Lin, D M Atrens, M J Christie, D M Jackson, Iain S. Mcgregor
Pharmacology, Biochemistry, and Behavior September 1993 DOI: 10.1016/0091-3057(93)90333-o (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational animal experiment (conditioned taste aversion paradigm) Peer reviewed |
|---|---|
| Population | Rats (number not stated) |
| Interventions | MDMA d-amphetamine |
| Dose | 0.125-2.0 mg/kg (SC) |
| Topics | MDMA |
| Key findings | MDMA produced dose-related conditioned taste aversions to saccharin, with a minimally effective dose of 1 mg/kg, compared to 0.5 mg/kg for d-amphetamine. The relative potency of MDMA to d-amphetamine was 4.5, similar to ratios previously reported for drug discrimination and self-stimulation. |
Abstract
Many drugs of abuse such as d-amphetamine support the development of taste aversion in a conditioned taste aversion paradigm. However, it has yet to be established whether methylenedioxymethamphetamine (MDMA), an amphetamine-like stimulant, has this property. A direct comparison was made between MDMA and d-amphetamine over a dose range of 0.125-2.0 mg/kg (SC). Two pairings of either drug with saccharin produced dose-related taste aversions to saccharin that were retained for at least three successive testing trials. The minimally effective dose was 1 mg/kg for MDMA and 0.5 mg/kg for d-amphetamine. The relative potency of MDMA to amphetamine was 4.5, similar to that previously reported for drug discrimination and self-stimulation.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 6
- Age differences in (±) 3,4‐methylenedioxymethamphetamine (MDMA)‐induced conditioned taste aversions and monoaminergic levels Developmental Psychobiology June 15, 2013
- Effects of Serial Polydrug Use on the Rewarding and Aversive Effects of the Novel Synthetic Cathinone Eutylone Brain Sciences September 7, 2023
- Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability. Pharmacology, Biochemistry, and Behavior October 2022
- Rats preexposed to MDMA display attenuated responses to its aversive effects in the absence of persistent monoamine depletions. Psychopharmacology August 2011
- 3,4-Methylenedioxy analogues of amphetamine: defining the risks to humans. Neuroscience and biobehavioral reviews March 1999
and 1 more in the library
Cites 6
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