Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum.
Psychopharmacology April 1995 DOI: 10.1007/bf02245967 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | MDMA L-deprenyl MDL-72974 |
| Measures | [3H]paroxetine binding Bmax, 5-HT levels, 5-HIAA levels |
| Topics | MDMA |
| Key points | MDMA alone significantly decreased striatal 5-HT uptake sites (Bmax for [3H]paroxetine binding) and 5-HT and 5-HIAA levels in rats. The MAO-B inhibitors L-deprenyl and MDL-72974 attenuated these decreases, suggesting to the authors that MAO-B plays a key role in MDMA-induced serotonergic neurotoxicity in the striatum. |
Abstract
The effects of the MAO-B inhibitors, L-deprenyl and MDL-72974 on MDMA-induced serotonergic neurotoxicity in rats were examined. MDMA alone produced a significant decrease in the number of 5-HT uptake sites, measured as a decrease in the Bmax for binding of [3H]paroxetine, and in 5-HT and 5-HIAA levels in the striatum. L-Deprenyl and MDL-72974 attenuated this MDMA-induced decrease in serotonergic markers. The data suggest a key role for MAO-B in the expression of the neurotoxicity produced by MDMA in the striatum.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 9
- Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice Synapse 2001
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- (±)-MDMA and its enantiomers: potential therapeutic advantages of R(-)-MDMA. Psychopharmacology February 2018
- Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. PLoS One November 18, 2016
- Effect of Some Psychoactive Drugs Used as ‘Legal Highs’ on Brain Neurotransmitters Neurotoxicity Research April 1, 2016
and 4 more in the library
Cites 4
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