Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice.
Cynthia Marie‐claire, Stefano Palminteri, Patrizia Romualdi, Florence Noble
Neuropharmacology June 2008 DOI: 10.1016/j.neuropharm.2008.03.001 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | MDMA SR142948A |
| Dose | MDMA 9 mg/kg; SR142948A 1 mg/kg |
| Duration | Up to 12 hours after acute injection; repeated exposure following CPP paradigm |
| Topics | MDMA |
| Key findings | The neurotensin receptor antagonist SR142948A inhibited MDMA-induced locomotor activity and abolished the expression of MDMA-conditioned place preference without affecting its acquisition. MDMA transiently up-regulated neurotensin mRNA in the striatum after acute injection, and repeated exposure increased mRNA levels, suggesting endogenous neurotensin mediates these behaviors. |
Abstract
Neurotensin is one of the genes previously found up-regulated in mice striatum after acute injection of MDMA (9 mg/kg). In order to examine the pharmacological significance of this effect, the involvement of the neurotensinergic system in MDMA-induced behaviors was explored in mice using the neurotensin receptor antagonist SR142948A (1mg/kg). We found that acute administration of the antagonist inhibited the MDMA-elicited locomotor activity. SR142948A pre-treatment had no effect on the acquisition of conditioned place preference (CPP) to MDMA but abolished the expression of this behavior. We also studied the effects of acute and repeated exposure to MDMA on the mRNA level of neurotensin in mice striatum. Kinetic analysis of the regulation 1, 2, 6 and 12h after acute injection of MDMA showed that the drug transiently up-regulates neurotensin mRNA in this structure. The time course of the modulation suggests that the effects observed with SR142948A are attributable to the release of a preexisting endogenous pool rather than the newly synthesized peptide. Repeated exposure to MDMA following the same injection pattern used in the CPP paradigm revealed an increase in mRNA level of neurotensin in mice striatum. These results indicate that endogenous neurotensin plays a role in both the acute locomotor activity and the expression of CPP induced by MDMA.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 4
- PRECLINICAL STUDY: Acquisition and reinstatement of MDMA‐induced conditioned place preference in mice pre‐treated with MDMA or cocaine during adolescence Addiction Biology September 8, 2009
- Of mice and men on MDMA: a translational comparison of the neuropsychobiological effects of 3,4-methylenedioxymethamphetamine ('Ecstasy'). Brain Research November 14, 2019
- Neurochemical substrates of the rewarding effects of MDMA: implications for the development of pharmacotherapies to MDMA dependence. Behavioural Pharmacology April 2016
- Characteristics of dual specificity phosphatases mRNA regulation by 3,4-methylenedioxymethamphetamine acute treatment in mice striatum. Brain Research November 6, 2008
Cites 2
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- Analysis of transcriptional responses in the mouse dorsal striatum following acute 3,4-methylenedioxymethamphetamine (ecstasy): identification of extracellular signal-regulated kinase-controlled genes. Neuroscience 2006