(±)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain.

Ann M. Hemmerle, Jonathan W. Dickerson, Nicole R Herring, Tori L. Schaefer, Charles V. Vorhees, Michael T. Williams, Kim B. Seroogy

J Comp Neurol August 1, 2012 DOI: 10.1002/cne.23048 (opens in new tab)

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Characteristics	Experimental study Peer reviewed
Population	Adult rats
Topics	MDMA
Citations	29
Key findings	MDMA treatment modulates the expression of neurotrophins and their receptors in multiple brain regions of adult rats.

Abstract

(±)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain.

Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression. Addict Biol 2011
Effects of 3,4‐methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity Journal of Neurochemistry November 30, 2009 47 citations
Some behavioural and neurochemical aspects of subacute (+/-)3,4-methylenedioxymethamphetamine administration in rats. Pharmacology, biochemistry, and behavior November 1995
Regulation of opioid gene expression in the rat brainstem by 3,4-methylenedioxymethamphetamine (MDMA): role of serotonin and involvement of CREB and ERK cascade. Naunyn-Schmiedeberg's archives of pharmacology February 2011
Analysis of transcriptional responses in the mouse dorsal striatum following acute 3,4-methylenedioxymethamphetamine (ecstasy): identification of extracellular signal-regulated kinase-controlled genes. Neuroscience 2006

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