Temporal dynamics of distinct CA1 cell populations during unconscious state induced by ketamine.
Hui Kuang, Longnian Lin, Joe Z. Tsien
PLoS One December 8, 2010 DOI: 10.1371/journal.pone.0015209 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational animal electrophysiology study Peer reviewed |
|---|---|
| Population | Mice, specifically hippocampal CA1 pyramidal cells and interneurons |
| Intervention | Ketamine |
| Topics | Ketamine Esketamine |
| Keywords | Hippocampus Pyramidal cells Interneurons Animals Mice, inbred c57bl Unconsciousness Analgesics Anesthesia Oscillometry Electrophysiology Synaptic transmission Time factors Male |
| Key findings | Ketamine induced distinct oscillatory dynamics in hippocampal CA1 pyramidal cells and in at least seven types of CA1 interneurons, including putative basket, chandelier, bistratified, and O-LM cells. The authors propose these emergent dynamics may reflect intrinsic temporal relationships within the CA1 circuit and could help explain how ketamine induces unconsciousness. |
Abstract
Ketamine is a widely used dissociative anesthetic which can induce some psychotic-like symptoms and memory deficits in some patients during the post-operative period. To understand its effects on neural population dynamics in the brain, we employed large-scale in vivo ensemble recording techniques to monitor the activity patterns of simultaneously recorded hippocampal CA1 pyramidal cells and various interneurons during several conscious and unconscious states such as awake rest, running, slow wave sleep, and ketamine-induced anesthesia. Our analyses reveal that ketamine induces distinct oscillatory dynamics not only in pyramidal cells but also in at least seven different types of CA1 interneurons including putative basket cells, chandelier cells, bistratified cells, and O-LM cells. These emergent unique oscillatory dynamics may very well reflect the intrinsic temporal relationships within the CA1 circuit. It is conceivable that systematic characterization of network dynamics may eventually lead to better understanding of how ketamine induces unconsciousness and consequently alters the conscious mind.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cites 7
- NMDA receptor regulation of memory and behavior in humans Hippocampus October 1, 2001
- Ketamine Disrupts Frontal and Hippocampal Contribution to Encoding and Retrieval of Episodic Memory: An fMRI Study Cerebral Cortex November 10, 2004
- Consciousness and Anesthesia Science November 7, 2008
- Circuit analysis of NMDAR hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia. Hippocampus 2001
- Acetylcholine in mind: a neurotransmitter correlate of consciousness? Trends in Neurosciences June 1999
and 2 more in the library