Slow EEG pattern predicts reduced intrinsic functional connectivity in the default mode network: an inter-subject analysis.
Jaroslav Hlinka, Charilaos Alexakis, Ana Diukova, Peter F. Liddle, Dorothee P Auer
Neuroimage June 9, 2010 DOI: 10.1016/j.neuroimage.2010.06.002 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 20 |
| Population | Healthy volunteers |
| Duration | 15-minute rest period |
| Measures | EEG band power, spectral edge frequency SEF95, BOLD functional connectivity |
| Topics | Default mode network |
| Keywords | Nerve net Humans Electroencephalography Brain mapping Biological clocks Rest Adolescent Female Young adult |
| Key findings | EEG band powers explained 70% of the variance in default mode network functional connectivity, with delta power negatively (r=-0.73) and beta power positively (r=0.53) correlated with DMN connectivity. The authors argue this identifies a distinct neurophysiological correlate of DMN functional connectivity and supports the biological relevance of network-specific intrinsic connectivity. |
Abstract
The last two decades have witnessed great progress in mapping neural networks associated with task-induced brain activation. More recently, identification of resting state networks (RSN) paved the way to investigate spontaneous task-unrelated brain activity. The cardinal features characterising RSN are low-frequency fluctuations of blood oxygenation level dependent (BOLD) signals synchronised between spatially distinct, but functionally connected brain areas. Simultaneous EEG/fMRI has been previously deployed to study the neurophysiological signature of RSN by comparing EEG power with BOLD amplitudes. We hypothesised that band-limited EEG power may be directly related to network-specific functional connectivity (FC) of BOLD signal time courses. Hence, we studied the association between individual EEG signature and FC in a core RSN, the so-called default mode network (DMN). Combined EEG/fMRI data of 20 healthy volunteers collected during a 15-minute rest period were analysed. Using an inter-subject analysis design, we demonstrated a network and frequency specific relation between RSN FC and EEG. In a multiple regression model, EEG band-powers explained 70% of DMN FC variance, with significant partial correlations of DMN FC to delta (r=-0.73) and beta (r=0.53) power. The identified EEG pattern has been previously associated with increased alertness. Conversely, an established EEG-derived sedation index (spectral edge frequency SEF95) closely correlated with DMN FC. The study presents an approach that opens a new perspective to EEG/fMRI correlation. Direct evidence was provided for a distinct neurophysiological correlate of DMN FC. This finding further validates the biological relevance of network-specific intrinsic FC and provides an initial neurophysiological basis for interpreting studies of DMN FC alterations.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |
Citations in the library
Cited by 3
- fMRI BOLD Correlates of EEG Independent Components: Spatial Correspondence With the Default Mode Network Frontiers in Human Neuroscience November 27, 2018
- The neurophysiological correlates of religious chanting. Scientific Reports March 12, 2019
- Default mode and frontal executive network interactions enable interoceptive attention & mindfulness
Cites 6
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Decoupling of the brain's default mode network during deep sleep Proceedings of the National Academy of Sciences June 19, 2009
- Frontal theta EEG activity correlates negatively with the default mode network in resting state International Journal of Psychophysiology July 13, 2007
- Development of the Brain's Default Mode Network from Wakefulness to Slow Wave Sleep Cerebral Cortex February 17, 2011
- BOLD correlates of EEG alpha phase-locking and the fMRI default mode network Neuroimage January 15, 2009
and 1 more in the library