Delta 9-tetrahydrocannabinol-induced alterations in limbic system glucose use in the rat.
Ros R Brett, F MacKenzie, Judith A Pratt
Neuroreport November 16, 2001 DOI: 10.1097/00001756-200111160-00040 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Delta9-tetrahydrocannabinol (THC) |
| Dose | 1 mg/kg and 5 mg/kg |
| Measures | [14C]2-deoxyglucose autoradiography |
| Topics | Cannabis |
| Key findings | THC at 5 mg/kg reduced local cerebral glucose use, especially in hippocampal, limbic, and sensorimotor regions; at 1 mg/kg it slightly increased glucose use overall and raised activity in the nucleus accumbens shell, suggesting dose-dependent effects on reward pathways. |
Abstract
The effects of Delta9-tetrahydrocannabinol (THC) on neural activity in the rat were investigated using [14C]2-deoxyglucose autoradiography to measure local cerebral glucose use. Overall, THC reduced glucose use at 5 mg/kg and slightly increased it at 1 mg/kg. Significant reductions were seen at the higher dose in regions of the hippocampus and limbic system, and in structures associated with sensory and sensorimotor process ing, consistent with the effects of THC on memory, sensory perception and motor control. Glucose use was increased in the shell of the nucleus accumbens at 1 mg/kg but not reduced at 5 mg/kg. This may reflect increases in activity in mesolimbic reward pathways which at the higher dose are mitigated by reduced glutamatergic outflow from the hippocampus.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.
Citations in the library
Cites 4
- Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication. Psychiatry Research May 31, 1996
- Effect of delta 9-tetrahydrocannabinol on short-term memory in the rat. Physiology & Behavior January 1995
- Pharmacological characterization of cannabinoids in the elevated plus maze. Journal of Pharmacology and Experimental Therapeutics June 1, 1990
- Determination and characterization of a cannabinoid receptor in rat brain. Molecular Pharmacology November 1, 1988