Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens.
Psychopharmacology April 7, 2010 DOI: 10.1007/s00213-010-1836-5 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Intervention | Salvinorin A |
| Topics | Salvia divinorum |
| Key findings | Salvinorin A produces depressive-like effects that are associated with decreased phasic dopamine release in the nucleus accumbens, suggesting that kappa opioid receptor activation reduces phasic dopamine signaling, which may underlie depressive-like behavior. |
Abstract
Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens.
Comparable studies
Other observational and cohort studies on salvia divinorum, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans. Adult female baboons | 2008 | Observational cohort | n = 6 |
| Salvia divinorum: effects and use among YouTube users. YouTube video posters using salvia | 2010 | Observational study using video analysis | n = 34 |
| In vitro stability and metabolism of salvinorin A in rat plasma. Rat plasma | 2009 | Observational study | |
| Salvia divinorum: exposures reported to a statewide poison control system over 10 years. Exposures to Salvia divinorum reported to the California Poison Control System | 2011 | Retrospective review | n = 37 |
| Time course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans. Healthy adults | 2016 | Observational study | n = 6 |
Citations in the library
Cited by 35
- Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism American Journal of Psychiatry August 29, 2018
- Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution Frontiers in Human Neuroscience May 23, 2017
- Clinical applications of hallucinogens: A review. Experimental and Clinical Psychopharmacology August 1, 2016
- Models of psychedelic drug action: modulation of cortical-subcortical circuits Brain October 22, 2021
- Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A. Pharmacological Reviews June 1, 2011
and 30 more in the library
Cites 7
- Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proceedings of the National Academy of Sciences September 3, 2002
- Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. Journal of Pharmacology and Experimental Therapeutics March 1, 2004
- Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors. Psychopharmacology May 1, 2005
- Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum. Psychopharmacology April 2008
- N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy. Journal of Pharmacology and Experimental Therapeutics January 2008
and 2 more in the library