Natural and Synthetic Ibogamines A Novel Approach to Treating Opioid Dependency
Stanley D Glick, Isabelle M Maisonneuve
April 25, 2008 DOI: 10.1093/oso/9780195300550.003.0014 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review |
|---|---|
| Topics | Ibogaine |
| Key findings | The abstract reports that ibogaine, an alkaloid from Tabernanthe iboga, was claimed in five U.S. patents issued between 1985 and 1992 to treat addiction to opioids, stimulants, alcohol, nicotine, and polydrug abuse, purportedly by abolishing craving and, for opioids, withdrawal symptoms. |
Abstract
Abstract Of several alkaloids found in the root bark of the African shrub Tabernanthe iboga, ibogaine has certainly attracted the most interest. Although it has a long history of use in Africa, in initiation rites and religious rituals of Bwiti and Mbiri cults, ibogaine became newsworthy in the United States only after it was claimed to be an effective treatment for addiction to a variety of other drugs. Five United States patents (numbers 4,499,096; 4,587,243; 4,857,523; 5,026,697; 5,124,994) issued between 1985 and 1992 claimed that ibogaine could be used to successfully treat opioid (heroin) addiction, stimulant (cocaine and amphetamine) abuse, alcohol dependence, cigarette smoking (nicotine dependence), and polydrug abuse. Ibogaine was said to interfere with the ‘‘physiological and psychological aspects’’ of addiction, abolishing the craving for drugs, and, at least in the case of opioids, abolishing withdrawal symptoms as well.
Comparable studies
Other narrative reviews on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelics as medicines for substance abuse rehabilitation: evaluating treatments with LSD, Peyote, Ibogaine and Ayahuasca. | 2014 | Review | |
| The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation Humans, animals | 2015 | Review | |
| Ibogaine in the treatment of substance dependence. | 2013 | Review | |
| Ibogaine, an anti-addictive drug: pharmacology and time to go further in development. A narrative review. | 2008 | Review | |
| Registered clinical studies investigating psychedelic drugs for psychiatric disorders. Registered clinical trials on clinicaltrials.gov evaluating psychedelics for... | 2021 | Review | n = 70 |