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Reduced 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-initiated oxidative DNA damage and neurodegeneration in prostaglandin H synthase-1 knockout mice.

ACS Chem Neurosci February 23, 2010 DOI: 10.1021/cn900022w (opens in new tab)

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AI-extracted from the abstract
Characteristics Preclinical experimental study Peer reviewed
Population Mice (PGHS-1 knockout and wild-type)
Intervention MDMA
Topics MDMA
Key findings PGHS-1 knockout mice exhibited reduced MDMA-initiated oxidative DNA damage and neurodegeneration compared to wild-type mice, indicating that PGHS-1 contributes to MDMA's neurotoxic effects.

Abstract

Reduced 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-initiated oxidative DNA damage and neurodegeneration in prostaglandin H synthase-1 knockout mice.

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