A role for adenosine A(1) receptor blockade in the ability of caffeine to promote MDMA "Ecstasy"-induced striatal dopamine release.
Eur J Pharmacol October 14, 2010 DOI: 10.1016/j.ejphar.2010.10.012 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Caffeine MDMA |
| Measures | striatal dopamine release |
| Topics | MDMA |
| Key findings | Adenosine A1 receptor blockade, but not A2A blockade, mimics caffeine's ability to enhance MDMA-induced striatal dopamine release in rats, indicating that caffeine's effect is mediated through A1 receptors. |
Abstract
A role for adenosine A(1) receptor blockade in the ability of caffeine to promote MDMA "Ecstasy"-induced striatal dopamine release.