Synthetic studies of psilocin analogs having either a formyl group or bromine atom at the 5- or 7-position.
Fumio Yamada, Mayumi Tamura, Atsuko Hasegawa, Masanori Somei
Chemical and Pharmaceutical Bulletin January 2002 DOI: 10.1248/cpb.50.92 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Key points | The authors report the first preparation of psilocin analogs bearing formyl or bromine groups at the 5- or 7-position, and establish synthetic routes for various brominated indole intermediates and N,N-dimethyltryptamine derivatives. |
Abstract
Psilocin analogs having either a formyl group (9-12) or a bromine atom (13-18) at the 5- or 7-position have been prepared for the first time. Syntheses of 5- and 7-bromo derivatives of 4-hydroxy- (23, 24, 28) and 4-benzyloxyindole-3-carbaldehyde (19, 25, 29, 30), 4-benzyloxyindole-3-acetonitriles (20, 31), and 4-benzyloxy-N,N-dimethyltryptamine (32, 34, 35) have also been established.
Comparable studies
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| REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics | 2019 | Theoretical or philosophical paper | |
| Psychedelics as Medicines: An Emerging New Paradigm General population | 2016 | Theoretical or philosophical paper | |
| Theorizing that Psychedelic Assisted Therapy May Play a Role in the Treatment of Trauma-Induced Personality Disorders. | 2024 | Theoretical or philosophical paper | |
| What Geometric Visual Hallucinations Tell Us about the Visual Cortex | 2002 | Theoretical or philosophical paper | |
| Psilocybin-assisted therapy of major depressive disorder using Acceptance and Commitment Therapy as a therapeutic frame | 2020 | Theoretical or philosophical paper |
Citations in the library
Cited by 4
- Occurrence and use of hallucinogenic mushrooms containing psilocybin alkaloids TemaNord May 19, 2009
- Enzymatic Route toward 6‐Methylated Baeocystin and Psilocybin ChemBioChem May 31, 2019
- A Review of Synthetic Access to Therapeutic Compounds Extracted from Psilocybe. Pharmaceuticals December 28, 2022
- Champignons hallucinogènes d'Europe et des Amériques : mise au point mycologique et toxicologique Annales de Toxicologie Analytique 2004