(PNM-42) Use of psychedelic drugs as an adjunct in couples psychotherapy and sex therapy
Journal of Sexual Medicine February 1, 2026 DOI: 10.1093/jsxmed/qdag002.118 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Qualitative Peer reviewed |
|---|---|
| Topics | Psychedelic-assisted therapy |
| Key findings | The authors suggest that psychedelics may moderate mood and affective, volitional, and cognitive processes relevant to patients in couples therapy and sex therapy, and describe a very favorable prognosis, especially in cases unresponsive to traditional pharmacological treatment. |
Abstract
Despite clinical investigations with psychedelics for severe cases of mood disorders and PTSD and current research suggesting such applicability, research on their application in couples therapy and sex therapy is scarce. The objective of this systematic review was to highlight these drugs as adjuvants for such patients. Literature research was conducted using the terms “couple’s therapy” or “sexual therapy” and “psychedelic” on Google Scholar (9 articles), RefSeek (11 articles), PubMed (0 articles), and CAPES Journals (0 articles) databases. Duplicated results and articles that did not directly address the use of psychedelics and their impact on sexual behavior or their use in couples’ psychotherapy or sex therapy were excluded. Eleven publications were found, including three clinical trials and two qualitative investigations with psychedelic users regarding their perception of the impact on sexual behavior and intimate relationships. A previous systematic review of clinical trials discussing the potential use of drugs in couples’ psychotherapy, as well as theoretical essays on the use of psychedelic drugs as adjuvants in couples’ psychotherapy (four articles) and sex therapy (one article) were identified. Reviewed works highlight four main themes: a) drugs effects; b) relevant characteristics for a psychedelic-assisted couples psychotherapy protocol; c) expected therapeutic effects and prognosis; and d) relevant aspects to be considered for regulation and professional training. Authors suggest moderating effects on mood and affective, volitional, and cognitive processes relevant to patients in couples’ psychotherapy and sex therapy. They also describe a very favorable prognosis, especially in cases unresponsive to traditional pharmacological treatment. However, they emphasize the importance of adequate clinical protocol, training competences properly and having a transdisciplinary team for assisted psychotherapies. No conflict.