Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study.
E. Garland, Myranda A Bryan, Sarah E. Priddy, Michael R. Riquino, Brett Froeliger, M. Howard
Annals of Behavioral Medicine January 22, 2019 DOI: 10.1093/abm/kay096 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled trial Randomized Peer reviewed |
|---|---|
| Sample size | 57 |
| Population | Adults with chronic pain and long-term prescription opioid use |
| Intervention | Mindfulness-Oriented Recovery Enhancement (MORE) |
| Duration | Pre- to post-treatment with 3-month follow-up |
| Topics | Meditation |
| Key findings | MORE significantly reduced errors of commission on trials with pain-related distractors compared with neutral distractors, indicating enhanced emotional response inhibition. |
Abstract
Background: Among opioid-treated chronic pain patients, deficient response inhibition in the context of emotional distress may contribute to maladaptive pain coping and prescription opioid misuse. Interventions that aim to bolster cognitive control and reduce emotional reactivity (e.g., mindfulness) may remediate response inhibition deficits, with consequent clinical benefits.
Purpose: To test the hypothesis that a mindfulness-based intervention, Mindfulness-Oriented Recovery Enhancement (MORE), can reduce the impact of clinically relevant, negative affective interference on response inhibition function in an opioid-treated chronic pain sample.
Methods: We examined data from a controlled trial comparing adults with chronic pain and long-term prescription opioid use randomized to either MORE (n = 27) treatment or to an active support group comparison condition (n = 30). Participants completed an Emotional Go/NoGo Task at pre- and post-treatment, which measured response inhibition in neutral and clinically relevant, negative affective contexts (i.e., exposure to pain-related visual stimuli).
Results: Repeated-measures analysis of variance indicated that compared with the support group, participants in MORE evidenced significantly greater reductions from pre- to post-treatment in errors of commission on trials with pain-related distractors relative to trials with neutral distractors, group × time × condition F(1,55) = 4.14, p = .047, η2partial = .07. Mindfulness practice minutes and increased nonreactivity significantly predicted greater emotional response inhibition. A significant inverse association was observed between improvements in emotional response inhibition and treatment-related reductions in pain severity by 3-month follow-up.
Conclusions: Study results provide preliminary evidence that MORE enhances inhibitory control function in the context of negative emotional interference.
Comparable studies
Other non-randomized and open-label trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Mindfulness-Based Stress Reduction in Relation to Quality of Life, Mood, Symptoms of Stress, and Immune Parameters in Breast and Prostate Cancer Outpatients Early-stage breast and prostate cancer patients | 2003 | Pre-post intervention study | n = 59 |
| Exploring self‐compassion and empathy in the context of mindfulness‐based stress reduction (MBSR) Community sample | 2010 | Pre-post intervention study | |
| Mindfulness-Based Stress Reduction Lowers Psychological Distress In Medical Students Second-year medical students | 2003 | Prospective nonrandomized cohort-controlled study | n = 302 |
| Intensive meditation training, immune cell telomerase activity, and psychological mediators. Retreat participants and matched controls | 2011 | Controlled trial with wait-list control group | n = 60 |
| The Effectiveness of Mindfulness Training for Children with ADHD and Mindful Parenting for their Parents Children aged 8-12 with ADHD and their parents | 2011 | Within-group waitlist controlled trial | n = 22 |
Citations in the library
Cited by 11
- Mindfulness-Oriented Recovery Enhancement remediates anhedonia in chronic opioid use by enhancing neurophysiological responses during savoring of natural rewards. Psychological Medicine April 1, 2023
- Mindfulness-based Interventions for Chronic Low Back Pain: A Systematic Review and Meta-analysis. Clinical Journal of Pain February 1, 2024
- Be more mindful: Targeting addictive responses by integrating mindfulness with cognitive bias modification or cue exposure interventions Neuroscience & Biobehavioral Reviews September 25, 2023
- The Effectiveness of Mindfulness in the Treatment of Methamphetamine Addiction Symptoms: Does Neuroplasticity Play a Role? Brain Sciences March 27, 2024
- Enhancing interoceptive awareness in chronic pain and opioid misuse via mindfulness-oriented recovery enhancement. Drug and Alcohol Dependence June 2, 2025
and 6 more in the library
Cites 18
- Using Self-Report Assessment Methods to Explore Facets of Mindfulness Assessment January 27, 2006
- Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness Frontiers in Human Neuroscience 2012
- Mindfulness and mind-wandering: Finding convergence through opposing constructs. Emotion February 6, 2012
- Cognitive-Affective Neural Plasticity following Active-Controlled Mindfulness Intervention Journal of Neuroscience October 31, 2012
- Enhanced response inhibition during intensive meditation training predicts improvements in self-reported adaptive socioemotional functioning. Emotion April 1, 2011
and 13 more in the library