The PCP site of the NMDA receptor complex.
J F MacDonald, M C Bartlett, I Mody, J N Reynolds, M W Salter
Advances in experimental medicine and biology January 1, 1990 DOI: 10.1007/978-1-4684-5769-8_4 (opens in new tab) via PubMed
Summary
AI-generated from the abstractElectropharmacological evidence suggests the PCP binding site is closely linked to the channel domain of the NMDA receptor, but it is too early to conclude the site lies deep within the NMDA channel pore. Determining the molecular details of the PCP site will require a complete kinetic analysis of NMDA single channel behavior. Additionally, hydrophobic receptor sites likely contribute to the blockade produced by some dissociative anesthetics.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Key finding | Argues that electropharmacological evidence favors the hypothesis that the PCP site is associated with the channel domain of the NMDA receptor, but that determining its molecular details requires further kinetic analysis. |
Abstract
Evidence from electropharmacological experimentation favors the hypothesis that the PCP site is intimately associated with the channel domain of the NMDA receptor. But it is too early to state that this site lies deep within the NMDA channel pore. Determining the molecular details of the PCP site will require a complete and detailed kinetic analysis of NMDA single channel behavior. Furthermore, it is likely that hydrophobic receptor site(s) are responsible for some aspects of the blockade by at least some members of the dissociative anaesthetic family.