The PCP site of the NMDA receptor complex.
J F MacDonald, M C Bartlett, I Mody, J N Reynolds, M W Salter
Advances in experimental medicine and biology 1990 DOI: 10.1007/978-1-4684-5769-8_4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Key findings | Argues that electropharmacological evidence favors the hypothesis that the PCP site is associated with the channel domain of the NMDA receptor, but that determining its molecular details requires further kinetic analysis. |
Abstract
Evidence from electropharmacological experimentation favors the hypothesis that the PCP site is intimately associated with the channel domain of the NMDA receptor. But it is too early to state that this site lies deep within the NMDA channel pore. Determining the molecular details of the PCP site will require a complete and detailed kinetic analysis of NMDA single channel behavior. Furthermore, it is likely that hydrophobic receptor site(s) are responsible for some aspects of the blockade by at least some members of the dissociative anaesthetic family.