[Analytical data of designated substances (Shitei-Yakubutsu) controlled by the Pharmaceutical Affairs Law in Japan, part I: GC-MS and LC-MS].
Ruri Kikura-Hanajiri, Maiko Kawamura, Nahoko Uchiyama, Jun Ogata, Hiroyuki Kamakura, Kazuhiro Saisho, Yukihiro Goda
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan June 1, 2008 DOI: 10.1248/yakushi.128.971 (opens in new tab) via PubMed
Summary
AI-generated from the abstractJapan's Ministry of Health, Labor and Welfare amended the Pharmaceutical Affairs Law in 2006 to control 31 non-controlled psychotropic substances and one plant as "Designated Substances" as of April 2007, with five more compounds added in January 2008. These substances had been sold as video cleaners, incense, and reagents via the Internet or in video shops. The authors developed simultaneous analytical methods using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) and present retention times, UV spectra, and mass spectrometry data for these substances.
Study at a glance
| Characteristics | Method development study Peer reviewed |
|---|---|
| Key finding | Presents GC-MS and LC-MS methods and spectral data for 36 designated substances and one plant controlled under Japan's Pharmaceutical Affairs Law. |
Abstract
In the last 10 years, many analogs of narcotic substances have been widely distributed in Japan as easily available psychotropic substances and this has become a serious problem. They have been sold as video cleaners, incense and reagents via the Internet or in video shops. They are not controlled under the Narcotics and Psychotropics Control Law because their pharmacological effects have not yet been proved scientifically. As a countermeasure to prevent the abuse of these substances, the Ministry of Health, Labor and Welfare amended the Pharmaceutical Affairs Law in 2006 so that 31 non-controlled psychotropic substances (11 tryptamines, 11 phenethylamines, 6 alkyl nitrites, 2 piperazines and salvinorin A) and 1 plant (Salvia divinorum) are now controlled as "Designated Substances (Shitei-Yakubutsu)" as of April 2007. Five other compounds (4 phenethylamines and 1 piperazine) were also added to this category in January 2008. In this study, we developed simultaneous analytical methods for these designated substances using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) and present retention times, UV spectra, electron ionization (EI), GC-MS, and electrospray ionization (ESI) LC-MS data.