"Word of mouse": indigenous harm reduction and online consumerism of the synthetic compound methoxphenidine.

Methoxphenidine (MXP), an NMDA antagonist marketed in 2013 as a legal replacement for methoxetamine (MXE), diphenidine, and ketamine, produces a dissociative and stimulant wave that can last for days. Analysis of seven self-reported experiences and 28 thread discussions from public Internet fora, using the Empirical Phenomenological Psychological method, identified five themes and 61 categories. Acute side-effects include hypertension and seizures; chronic effects include long-term memory loss and limb numbness. A sense of empowerment occurs in the afterglow. Internet drug fora facilitate information exchange, informed consumerism, and indigenous harm reduction, supporting pre- and post-purchase decision making.

Study at a glance

Abstract

Methoxphenidine (MXP) was one of several NMDA antagonists marketed in 2013 to replace the recently controlled compound Methoxetamine (MXE). A steep rise in user interest was recorded, despite vendor cautioning of limited user feedback. The study presented a phenomenological analysis of MXP experiences amongst recreational drug users as posted on public Internet fora. Internet searches were carried out using specific key words; "methoxphenidine," "MXP" and in combination with "experience," "report," "forum," and "trip." Seven self-reported experiences and 28 thread discussions relating sole use of MXP were analyzed using the Empirical Phenomenological Psychological method. Five themes and 61 categories emerged. MXP is marketed as a legal replacement for MXE, diphenidine, and ketamine, with a dissociative and stimulant wave outcome often lasting for days. Harm reduction tactics, awareness of prior tolerance to dissociative and optimal settings for use are discussed. Acute side-effects relate to hypertension and seizures. Chronic long-term memory loss and limb numbness is reported. Sense of empowerment occurs in the afterglow experience. Internet drug fora fuel information exchange and informed consumerism of synthetic compounds, and offer viable mechanisms for pre- and post-purchase decision making and indigenous harm reduction. Continued surveillance of synthetic market entries and user trends is warranted.