Psychedelic Properties of Peganum Harmala: Macrodose and Microdose Reports

Peganum harmala, a plant used for millennia in traditional medicine and religious rites, shows potential as an antidepressant and anxiolytic agent. At high doses it is entheogenic, producing profound psychedelic experiences with lasting positive effects similar to other psychedelics. Anecdotal evidence suggests it may offer benefits akin to microdosing other psychedelics, but no prior research has examined this. This paper provides the first evidence of P. harmala's effects when used in a daily microdosing protocol.

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Abstract

Peganum harmala has been used for millennia in traditional medicine and religious rites. Recent phytopharmaceutical research has given credence to its traditional uses, demonstrating a wide range of potential therapeutic uses, including its use as antidepressant and anxiolytic agent. Entheogenic at high doses, P. harmala can create profound psychedelic experiences with lasting positive effects that echo those seen in research on other psychedelics. Anecdotal evidence from online forums suggests P. harmala may be able to provide results similar to microdosing other psychedelics, though no research exists on this potential. This paper presents the first evidence of P. harmala’s effects when used in a daily microdosing protocol. KEY WORDS Peganum harmala, Syrian rue, macrodose, microdose, EEG, psychedelic, entheogen, affect, burnout, extraction.