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Effectiveness of a structured meditation programme in reducing anxiety symptoms: A randomized controlled trial among adults with generalized anxiety disorder

Sasmita Rout, Prabhanshu .

International Journal of Advanced Psychiatric Nursing February 1, 2026 DOI: 10.33545/26641348.2026.v8.i2a.243 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial Peer reviewed
Sample size 110
Population Adults aged 25–50 diagnosed with generalized anxiety disorder
Intervention guided meditation sessions
Duration 8-week intervention, 4-week follow-up
Topics Anxiety Meditation
Keywords Randomized controlled trial Psychological intervention Mental health Clinical psychology Rating scale Physical therapy Intervention counseling Anxiety score Clinical trial
Key findings An 8-week structured meditation programme significantly reduced anxiety symptoms and improved psychological well-being in adults with generalized anxiety disorder compared to usual care.

Abstract

Background: Anxiety disorders are among the most prevalent mental health conditions globally. Non-pharmacological therapies such as meditation are gaining recognition as effective adjuncts to standard treatment.

Objective: To examine the effectiveness of an 8-week structured meditation programme in reducing anxiety symptoms and enhancing psychological well-being among adults diagnosed with generalized anxiety disorder (GAD).

Methods: A randomized controlled trial was conducted among 110 adults aged 25–50 years. Participants were assigned to either an experimental group (n = 55), which received guided meditation sessions for eight weeks, or a control group (n = 55), which received usual care. Anxiety levels were measured using the Hamilton Anxiety Rating Scale (HAM-A) and the Generalized Anxiety Disorder Scale (GAD-7), while psychological well-being was assessed using the World Health Organization Well-being Index (WHO-5) at pre-test, post-test, and 4-week follow-up.

Results: The experimental group demonstrated a significant reduction in anxiety scores (HAM-A: M = 25.9 ? 18.0, t = 9.32, p<.001; GAD-7: M = 13.8 ? 9.4, t = 8.17, p<.001). Between-group comparisons also revealed significant differences in post-test mean anxiety scores (p<.001). WHO-5 scores increased by 31.2% in the experimental group compared with 9.8% in the control group.

Conclusion: The structured meditation programme significantly reduced anxiety and improved overall well-being among adults with GAD. The findings support the integration of meditation into clinical and nursing interventions for holistic mental health care.

Comparable studies

Other randomized controlled trials on anxiety, most cited first.

Study Year Design Participants
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Hallucinogen-naïve adults reporting regular participation in religious or spiritual... 2006 Double-blind study n = 36
Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer Adults with advanced-stage cancer and anxiety 2010 Double-blind, placebo-controlled study n = 12

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