BMRMI Reduces Depressive Rumination Possibly through Improving Abnormal FC of Dorsal ACC.
Ming-Hao Yang, Zhi-Peng Guo, Xue-Yu Lv, Zhu-Qing Zhang, Wei-Dong Wang, Jian Wang, Lan Hong, Ying-Na Lin, Chun-Hong Liu
Neural Plasticity 2022 DOI: 10.1155/2022/8068988 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort with intervention Peer reviewed |
|---|---|
| Sample size | 49 |
| Population | Adults with major depressive disorder and rumination, and healthy controls |
| Intervention | Body-mind relaxation meditation induction (BMRMI) |
| Key findings | Body-mind relaxation meditation induction altered functional connectivity of the dorsal anterior cingulate cortex in people with major depressive disorder and rumination, with changes linked to rumination scores. |
Abstract
Rumination is a common symptom of major depressive disorder (MDD) and has been characterized as a vulnerability factor for the onset or recurrence of MDD. However, the neurobiological mechanisms underlying rumination and appropriate treatment strategies remain unclear. In the current study, we used resting-state functional magnetic resonance imaging to investigate the effects of body-mind relaxation meditation induction (BMRMI) intervention in MDD with rumination. To this aim, we have recruited 25 MDD and 24 healthy controls (HCs). Changes in functional connectivity (FC) of the anterior cingulate cortex (ACC) subregion and the scores of clinical measurements were examined using correlation analysis. At baseline, MDD showed stronger FC between the right dorsal ACC (dACC) and right superior frontal gyrus than did the HC group. Compared to baseline, the HC group showed a significantly enhanced FC between the right dACC and right superior frontal gyrus, and the MDD group demonstrated a significantly weaker FC between the left dACC and right middle frontal gyrus (MFG) after the intervention. Furthermore, the FC between the right dACC and right superior frontal gyrus was positively associated with rumination scores across all participants at baseline. The above results indicate that BMRMI may regulate self-referential processing and cognitive function through modulating FC of the dACC in MDD with rumination.