Amazonian Ayahuasca and Mental Health Outcomes
June 17, 2024 DOI: 10.25602/gold.00032552 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review and observational study |
|---|---|
| Population | Ayahuasca tourists at Shipibo-style retreats in the Peruvian Amazon |
| Intervention | Ayahuasca |
| Topics | Ayahuasca |
| Keywords | Psychedelic-medicine Indigenous-healing Mental-health Ethnobotany Consciousness-research |
| Key findings | Complex synergistic mechanisms may be present in ayahuasca's pharmacology, and observational studies document effects on personality, mental health, epigenetics, and nature relatedness in retreat participants. |
Abstract
Ayahuasca is a psychedelic plant brew originating from the Amazon Rainforest. It is formed from two basic components, the Banisteriopsis caapi vine, and a plant containing the potent psychedelic dimethyltryptamine (DMT), usually Psychotria viridis. There has been a dramatic increase in interest surrounding ayahuasca since the turn of the millennium. Increasing numbers of tourists are travelling to the Amazon rainforest to drink the brew, with various media outlets, celebrities, and researchers describing benefit from its consumption. Ayahuasca is now present in every continent and retreat centres offering plant medicine experiences in the Amazon rainforest has become a thriving business. Anecdotal evidence varies significantly, ranging from evangelical accounts to horror stories involving physical and psychological harm. This thesis comprises five studies investigating Amazonian ayahuasca use. Initially, the pharmacology of the brew is explored in the form of a systematic review, concluding complex synergistic mechanisms may be present, although further research is needed. The remaining studies utilise observational methodology, investigating the impact of ayahuasca retreats following a traditional Shipibo lineage adapted for ayahuasca tourists in the Peruvian Amazon. The effects of the brew on personality, mental health outcomes, epigenetics, and nature relatedness are documented. Further, a phenomenological analysis of the ayahuasca experience is included. The research in this thesis is amongst the first to investigate Shipibo-style ayahuasca retreats in the Peruvian Amazon. Various ethical issues surrounding the increasing popularity of the brew and potential medicalisation are also discussed. It is hoped that this research will add to the growing body of knowledge surrounding the potential therapeutic effects of ayahuasca, whilst considering risks, ethics, and wider applications
Comparable studies
Other systematic reviews and meta-analyses on ayahuasca, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years Patients from included clinical trials | 2016 | Systematic review | |
| Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids Humans (ritual ayahuasca use) | 2006 | Systematic review | |
| Default Mode Network Modulation by Psychedelics: A Systematic Review Participants from included studies | 2022 | Systematic review | |
| Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies | 2017 | Systematic review | |
| Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis. Participants in studies of psychedelic therapy for depressive symptoms (Major... | 2023 | Systematic review with meta-analysis | n = 14 |