Mindfulness-Based Cognitive Therapy in Clinical Practice: A Systematic Review of Neurocognitive Outcomes and Applications for Mental Health and Well-Being.
Evgenia Gkintoni, Stephanos P. Vassilopoulos, Georgios Nikolaou
Journal of Clinical Medicine March 3, 2025 DOI: 10.3390/jcm14051703 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Intervention | Mindfulness-based cognitive therapy (MBCT) |
| Topics | Meditation Neuroplasticity |
| Keywords | Mental health Cognitive therapy |
| Citations | 64 |
| Key findings | Across 87 studies, the authors report that MBCT reduces depression, anxiety, and stress symptoms and improves cognitive function and emotional regulation in diverse populations. They propose that these effects may involve neuroplastic brain changes and argue for further research on long-term benefits and neurobiological mechanisms. |
Abstract
Background/Objectives: This systematic review outlines the neurocognitive outcomes and mechanisms of mindfulness-based cognitive therapy (MBCT) that influence subjective well-being. MBCT is a clinical intervention that integrates cognitive therapy with mindfulness practices to prevent depression relapses and improve mental health.
Methods: The review focuses on the effects of MBCT on brain structure changes, cognitive processes, and emotional regulation, which are related to improvements in subjective well-being. A total of 87 studies were included in the review to assess the effectiveness of MBCT.
Results: Evidence from the studies highlights the effectiveness of MBCT in reducing symptoms of depression, anxiety, and stress. MBCT was also shown to enhance cognitive functions and emotional regulation across diverse populations. These findings point to the potential for MBCT to induce neuroplastic changes in the brain and widen the applicability of the treatment for a variety of disorders, calling for further research into long-term benefits and underlying neurobiological mechanisms.
Conclusions: The review emphasizes the potential of MBCT to bring about neuroplastic changes, calling for further research into its long-term benefits and the underlying neurobiological mechanisms. This study underlines the need to incorporate multidisciplinary measures by integrating psychology and neuroscience to comprehend comprehensively the effects of MBCT.
Comparable studies
Other systematic reviews and meta-analyses on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Meditation Programs for Psychological Stress and Well-being Diverse adult clinical populations | 2014 | Meta-analysis | n = 3,515 |
| Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis Healthy subjects | 2009 | Systematic review and meta-analysis | |
| The psychological effects of meditation: A meta-analysis. Nonclinical groups of adult meditators | 2012 | Meta-analysis | n = 163 |
| Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse Adults with recurrent depression in full or partial remission | 2016 | Meta-analysis of individual patient data from randomized controlled trials | n = 1,258 |
| Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy – a systematic review of randomized controlled trials | 2011 | Systematic review |
Citations in the library
Cited by 20
- Positive Psychology Interventions in Early-Stage Cognitive Decline Related to Dementia: A Systematic Review of Cognitive and Brain Functioning Outcomes of Mindfulness Interventions. Brain Sciences May 28, 2025
- Deconstructive meditations and psychotherapy: Transforming the perception of the self. World Journal of Psychiatry June 19, 2025
- The convergent neuroscience of Christian prayer and attachment relationships in the context of mental health: a systematic review. Frontiers in Psychology 2025
- Mindfulness in the Brazilian National Health System (SUS): Why Training Instructors Is Not Expensive but Strategic and Cost-Effective Qeios August 31, 2026
- Advanced meditation, sleep, and consciousness science: An emerging frontier. Neuroscience & Biobehavioral Reviews August 1, 2026
and 15 more in the library
Cites 100
- Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse JAMA Psychiatry April 28, 2016
- Mindfulness-based interventions: an overall review British Medical Bulletin April 21, 2021
- Research Review: The effects of mindfulness‐based interventions on cognition and mental health in children and adolescents – a meta‐analysis of randomized controlled trials Journal of Child Psychology and Psychiatry October 22, 2018
- Home practice in Mindfulness-Based Cognitive Therapy and Mindfulness-Based Stress Reduction: A systematic review and meta-analysis of participants' mindfulness practice and its association with outcomes Behaviour Research and Therapy May 10, 2017
- A systematic review of the neurophysiology of mindfulness on EEG oscillations Neuroscience & Biobehavioral Reviews 2015
and 95 more in the library