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Interactions between classic psychedelics and serotonergic antidepressants: Effects on the acute psychedelic subjective experience, well-being and depressive symptoms from a prospective survey study.

Jessica Barbut Siva, Tommaso Barba, Hannes Kettner, Joanna Kuć, David Nutt, Robin Carhart-Harris, David Erritzøe

J Psychopharmacol January 27, 2024 DOI: 10.1177/02698811231224217 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Prospective survey study Peer reviewed
Population Adults who used classic psychedelics, some taking serotonergic antidepressants
Interventions classic psychedelics serotonergic antidepressants
Topics Serotonin
Keywords Psychedelics Antidepressants Mental health Drug interactions Psychiatric treatment
Citations 29
Key findings Serotonergic antidepressants reduce the intensity of acute psychedelic subjective experiences but do not prevent improvements in well-being and depressive symptoms.

Abstract

Interactions between classic psychedelics and serotonergic antidepressants: Effects on the acute psychedelic subjective experience, well-being and depressive symptoms from a prospective survey study.