Speech markers of psychedelic-induced psychological change
Joanna Kuć, Rosalind McAlpine, Amelia Sellers, George Blackburne, Daniel R Lametti, Jeremy I Skipper
bioRxiv April 21, 2025 preprint DOI: 10.1101/2025.04.16.649217 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Longitudinal observational study |
|---|---|
| Sample size | 29 |
| Population | Adults participating in a 5-MeO-DMT retreat |
| Intervention | 5-MeO-DMT |
| Dose | 1×12 mg |
| Duration | Two weeks before and two weeks after the 5-MeO-DMT session |
| Keywords | Psychedelics Mental health Linguistics Cognitive science Communication patterns |
| Key findings | Speech markers shifted toward increased cognitive language and decreased social words, and voice quality changed, with baseline features predicting psychological outcomes after 5-MeO-DMT. |
Abstract
Abstract 5-MeO-DMT, a potent, short-acting psychedelic, induces profound shifts in cognition, affect, and self-awareness. Because language explicitly expresses these domains and voice implicitly conveys them, both may serve as potential ‘biomarkers’ of behavioural change. This study introduces a novel framework for analysing baseline language and vocal features, pre- to post-psychedelic changes, assessing their potential to predict subjective experiences and psychological outcomes. Daily voice journals from 29 participants were collected via ‘RetreatBot’ for two weeks before and after 5-MeO-DMT (1×12 mg). Transcripts were analysed using NLP (bag-of-words for vocabulary; transformer model for textual affect), and acoustic features (e.g., pitch, jitter, shimmer) were extracted to assess vocal dynamics. Following 5-MeO-DMT, speech markers revealed increased cognitive language, decreased social words, and altered voice quality (increased jitter/shimmer). Baseline speech patterns predicted psychological preparedness, ego dissolution anxiety, emotional breakthrough, and post-experience well-being. This first longitudinal analysis of speech markers following psychedelic use demonstrates a shift from external focus to introspection. Speech markers predicted and tracked psychological transformation, establishing vocal journaling as a valuable framework for monitoring psychedelic-induced changes and facilitating integration.