Ketamine alters oscillatory coupling in the hippocampus
Fábio V. Caixeta, Alianda Maira Cornélio, Robson Scheffer-Teixeira, Sidarta Ribeiro, Adriano B. L. Tort
Scientific Reports August 2, 2013 DOI: 10.1038/srep02348 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Awake rats |
| Intervention | Ketamine |
| Dose | 25, 50 and 75 mg/kg i.p. |
| Topics | Ketamine Esketamine |
| Keywords | Hippocampal formation Hippocampus Coupling piping Nmda receptor Schizophrenia object-oriented programming |
| Citations | 134 |
| Key findings | Ketamine alters theta-gamma and theta-high-frequency coupling in the rat hippocampus in a dose-dependent manner, with theta-gamma coupling disrupted at the highest dose. |
Abstract
Recent studies show that higher order oscillatory interactions such as cross-frequency coupling are important for brain functions that are impaired in schizophrenia, including perception, attention and memory. Here we investigated the dynamics of oscillatory coupling in the hippocampus of awake rats upon NMDA receptor blockade by ketamine, a pharmacological model of schizophrenia. Ketamine (25, 50 and 75 mg/kg i.p.) increased gamma and high-frequency oscillations (HFO) in all depths of the CA1-dentate axis, while theta power changes depended on anatomical location and were independent of a transient increase of delta oscillations. Phase coherence of gamma and HFO increased across hippocampal layers. Phase-amplitude coupling between theta and fast oscillations was markedly altered in a dose-dependent manner: ketamine increased hippocampal theta-HFO coupling at all doses, while theta-gamma coupling increased at the lowest dose and was disrupted at the highest dose. Our results demonstrate that ketamine alters network interactions that underlie cognitively relevant theta-gamma coupling.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cited by 22
- Mechanisms of Ketamine Action as an Antidepressant Molecular Psychiatry March 13, 2018
- The neurophysiology of ketamine: an integrative review Reviews in the Neurosciences May 5, 2020
- EEG Gamma Band Alterations and REM-like Traits Underpin the Acute Effect of the Atypical Psychedelic Ibogaine in the Rat. ACS Pharmacology & Translational Science April 9, 2021
- Repurposing General Anesthetic Drugs to Treat Depression: A New Frontier for Anesthesiologists in Neuropsychiatric Care. Anesthesiology August 1, 2024
- Is the antidepressant effect of ketamine separate from its psychotomimetic effect? A review of rodent models. Neuropharmacology November 1, 2024
and 17 more in the library
Cites 7
- Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans Archives of General Psychiatry March 1, 1994
- Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Journal of Neuroscience April 15, 1997
- Is the Acute NMDA Receptor Hypofunction a Valid Model of Schizophrenia? Schizophrenia Bulletin September 28, 2011
- Ketamine disrupts θ modulation of γ in a computer model of hippocampus. Journal of Neuroscience August 10, 2011
- Acute administration of typical and atypical antipsychotics reduces EEG γ power, but only the preclinical compound LY379268 reduces the ketamine-induced rise in γ power. The International Journal of Neuropsychopharmacology June 9, 2011
and 2 more in the library