Is It Time to Advance the Chemoprevention of Environmental Carcinogenesis with Microdosing Trials?
Thomas W. Kensler, John D. Groopman
Cancer Prevention Research December 1, 2009 DOI: 10.1158/1940-6207.capr-09-0232 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Perspective Peer reviewed |
|---|---|
| Topics | Microdosing |
| Key points | Proposes that microdosing with environmental carcinogens can accelerate evaluation and optimization of chemopreventive interventions. |
Abstract
Abstract This perspective on Jubert et al. (beginning on page [1015] in this issue of the journal) discusses the use of microdosing with environmental carcinogens to accelerate the evaluation and optimization of chemopreventive interventions. The need for chemoprevention of environmental carcinogenesis is considered, as are the structure of microdosing, or phase 0, trials, technologies required to conduct microdose studies in this context, and ethical concerns. We also reflect on what microdosing studies have taught us to date.