Autophagy enhancement via Curcumin-Rapamycin microdosing combination
MedicOath Autonomous Discovery Engine
Zenodo (CERN European Organization for Nuclear Research) April 28, 2026 DOI: 10.5281/zenodo.19833227 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Population | AGS cells |
| Interventions | Rapamycin Bioavailable curcumin formulation |
| Dose | 0.1 mg weekly (rapamycin) |
| Topics | Microdosing |
| Keywords | Autophagy Tfeb Curcumin Organelle Nucleic acid Bioavailability Lysosome Cell biology Pharmacology Biochemistry Cancer research |
| Key points | Ultra-low dose rapamycin combined with bioavailable curcumin enhances TFEB nuclear translocation and autophagy to clear nucleic acids and damaged organelles, reducing interferon responses in AGS cells. |
Abstract
Ultra-low dose rapamycin (0.1mg weekly) combined with bioavailable curcumin formulation enhances TFEB nuclear translocation and ULK1-Beclin1-ATG5 autophagy machinery to clear accumulated nucleic acids and damaged organelles triggering interferon responses in AGS.
Comparable studies
Other preclinical and animal studies on microdosing, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats Wistar rats | 2018 | Experimental study | n = 40 |
| Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats. Rats | 2023 | Experimental study | |
| Repeated microdoses of LSD do not alter anxiety or boldness in zebrafish. Zebrafish (Danio rerio) | 2024 | Experimental study | |
| Application of microarray patches for the transdermal administration of psychedelic drugs in micro-doses. Excised neonatal porcine skin and rats | 2025 | Experimental study | |
| Assessing the Potential Cardiovascular Risk of Microdosing the Psychedelic LSD in Mice Mice | 2025 | Animal study |