Autophagy Enhancement with Spermidine and Rapamycin Microdosing
MedicOath Autonomous Discovery Engine
Zenodo (CERN European Organization for Nuclear Research) April 28, 2026 DOI: 10.5281/zenodo.19833033 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Microdosing |
| Keywords | Autophagy Spermidine Pi3k/akt/mtor pathway Mitochondrion Atg5 Cell biology Biochemistry |
| Key points | Proposes that combining spermidine and ultra-low dose rapamycin could enhance autophagy to clear toxic metabolites and misfolded proteins in mevalonic aciduria and improve mitochondrial quality control. |
Abstract
Spermidine induces autophagy through mTOR-independent mechanisms while ultra-low dose rapamycin provides mTOR inhibition. Enhanced autophagy could clear accumulated metabolites and misfolded proteins in mevalonic aciduria while supporting cellular energy homeostasis through improved mitochondrial quality control.
Comparable studies
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|---|---|---|---|
| Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development | 2003 | Theoretical or philosophical paper | |
| Set and setting in microdosing: an oft-overlooked principle. | 2022 | Theoretical or philosophical paper | |
| Daily Psilocybin Microdosing as a Receptor-Adaptation Paradigm: A Testable 5-HT2A Down-Regulation Hypothesis | 2026 | Theoretical or philosophical paper | |
| It’s all about the relationship: The caregiver experience of supporting a person with advanced cancer going through an LSD microdosing trial Caregivers of advanced cancer patients in an LSD microdosing trial | 2026 | Theoretical or philosophical paper | |
| Microdosing psychedelics: More questions than answers? An overview and suggestions for future research | 2019 | Theoretical or philosophical paper |